Jamdade Kshitij, Hashi Amal, Deo Nandita
Department of Gynaecological Oncology, Nottingham University Hospitals NHS Trust, City Hospital, Nottingham NG5 1PB, UK.
Department of Gynaecological Oncology, Barts Health NHS Trust, Whipps Cross Hospital, London E11 1NR, UK.
J Clin Med. 2025 Mar 30;14(7):2383. doi: 10.3390/jcm14072383.
Borderline ovarian tumours (BOTs) are a unique subset of epithelial ovarian neoplasms characterised by atypical epithelial proliferation without stromal invasion. BOTs are typically diagnosed at an early stage, primarily affect women of reproductive age, and have a favourable prognosis. This study aims to evaluate the clinical characteristics, surgical management, and outcomes of BOTs in a North East London cohort. A retrospective, multicentric analysis was conducted on 69 patients with histologically confirmed BOTs managed between January 2018 and December 2022 across the Barts Health NHS Trust hospitals. Clinical and demographic data, surgical details, histopathological findings, and recurrence rates were analysed. We used descriptive and exploratory statistical methods. The mean age at diagnosis was 44 years, with 46.37% under 40, including 18 nulliparous women. Most tumours (91.3%) were FIGO stage I, with mucinous histology predominating (56.52%), followed by serous BOTs (27.53%). Ultrasound and MRI demonstrated 65.45% and 81.5% sensitivities for borderline or malignant features, respectively. Surgical approaches included open surgery (75.4%), laparoscopy (17.4%), and robotic-assisted procedures (2.9%). Fertility-sparing surgery (FSS) was performed in all nulliparous women under 40 years of age. Recurrence occurred in 2 cases, both in patients with prior FSS performed over a decade earlier. FSS is a viable option for young women, especially if nulliparous and under the age of 40, with recurrence rates comparable to radical procedures. Most patients were diagnosed early (FIGO I) with excellent prognoses. MRI proved most sensitive for diagnosis, while long-term follow-up with transvaginal ultrasound and CA-125 monitoring is crucial for detecting recurrences.
交界性卵巢肿瘤（BOTs）是上皮性卵巢肿瘤中的一个独特亚组，其特征为非典型上皮增生但无基质浸润。BOTs通常在早期被诊断出来，主要影响育龄女性，且预后良好。本研究旨在评估伦敦东北部一组人群中BOTs的临床特征、手术治疗及预后情况。对2018年1月至2022年12月期间在巴茨健康国民保健服务信托基金医院接受治疗的69例经组织学确诊为BOTs的患者进行了一项回顾性多中心分析。分析了临床和人口统计学数据、手术细节、组织病理学结果及复发率。我们采用了描述性和探索性统计方法。诊断时的平均年龄为44岁，46.37%的患者年龄在40岁以下，其中包括18例未生育女性。大多数肿瘤（91.3%）为国际妇产科联盟（FIGO）I期，黏液性组织学类型占主导（56.52%），其次是浆液性BOTs（27.53%）。超声和磁共振成像（MRI）对交界性或恶性特征的敏感性分别为65.45%和81.5%。手术方式包括开放手术（75.4%）、腹腔镜手术（17.4%）和机器人辅助手术（2.9%）。所有40岁以下的未生育女性均接受了保留生育功能手术（FSS）。2例患者出现复发，均为十多年前曾接受过FSS的患者。FSS对年轻女性是一种可行的选择，尤其是未生育且年龄在40岁以下的女性，其复发率与根治性手术相当。大多数患者早期（FIGO I期）被诊断出来，预后良好。MRI被证明对诊断最敏感，而经阴道超声和CA - 125监测的长期随访对于检测复发至关重要。
