Chatterjee Tanima, Zarjou Abolfazl
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Adv Kidney Dis Health. 2025 Mar;32(2):122-132. doi: 10.1053/j.akdh.2024.12.004.
Acute kidney injury, a rapid decline in kidney function coupled with physiological and homeostatic perturbations, is an independent risk factor for both short-term and long-term health outcomes. As incidence of acute kidney injury continues to rise globally, the significant clinical and economic challenge of acute kidney injury underscores the need for its prompt recognition and application of novel and germane strategies to reduce its severity and facilitate recovery. Understanding the multifaceted cascade of events engaged in pathogenesis of acute kidney injury is pivotal for the development of effective preventive and therapeutic strategies. To facilitate an in-depth discussion on emerging therapeutic targets, this review will examine the role of macrophages in kidney injury and repair, explore the alterations in mitochondrial biogenesis dynamics induced by acute kidney injury, and provide insights into the molecular mechanisms underlying the contribution of ferroptosis to kidney injury.
急性肾损伤是指肾功能迅速下降并伴有生理和内环境稳态紊乱，它是短期和长期健康结局的独立危险因素。随着全球急性肾损伤的发病率持续上升，急性肾损伤带来的重大临床和经济挑战凸显了迅速识别并应用新颖且相关策略以降低其严重程度并促进恢复的必要性。了解参与急性肾损伤发病机制的多方面事件级联对于制定有效的预防和治疗策略至关重要。为便于深入讨论新兴治疗靶点，本综述将研究巨噬细胞在肾损伤和修复中的作用，探讨急性肾损伤诱导的线粒体生物发生动力学变化，并深入了解铁死亡对肾损伤作用的分子机制。
