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急性肾损伤的连续性肾脏替代治疗:一例病例报告。

Continuous renal replacement therapy for acute kidney injury: a case report.

作者信息

Wang Jianmin, Bao Yiyao, Guan Lijun, Tan Linhua

机构信息

Department of Surgical ICU, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

出版信息

Transl Pediatr. 2025 Mar 31;14(3):494-499. doi: 10.21037/tp-2024-500. Epub 2025 Mar 26.

DOI:10.21037/tp-2024-500
PMID:40225078
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11982988/
Abstract

BACKGROUND

Acute kidney injury is a severe complication of pediatric trauma with complex and diverse mechanisms and is associated with multiple organ dysfunction. For severely injured children, renal function should be closely monitored, and continuous renal replacement therapy should be promptly initiated if there is a risk of developing severe acute kidney injury. This case report describes the treatment process of a child with acute kidney injury due to trauma, highlighting the need to improve the rapid identification of traumatic acute kidney injury risk and actively implement resuscitation strategies to protect renal function in trauma patients.

CASE DESCRIPTION

A 3-year-old boy presented with acute kidney injury following a car accident. Multi-organ dysfunction developed, and laparotomy and liver laceration repair were performed. Continuous renal replacement therapy for 7 days, plasma exchange, antimicrobial therapy, and multi-organ support were provided. A 1-year follow-up showed no organ dysfunction.

CONCLUSIONS

This case report describes the treatment process of a child with acute kidney injury due to trauma, highlighting the need to improve the rapid identification of traumatic acute kidney injury risk and actively implement resuscitation strategies to protect renal function in patients with trauma. Prompt continuous renal replacement therapy should be considered when necessary to prevent adverse outcomes.

摘要

背景

急性肾损伤是小儿创伤的严重并发症,机制复杂多样,且与多器官功能障碍相关。对于重伤儿童,应密切监测肾功能,若有发生严重急性肾损伤的风险,应及时启动连续性肾脏替代治疗。本病例报告描述了一名因创伤导致急性肾损伤患儿的治疗过程,强调了提高对创伤性急性肾损伤风险快速识别的必要性,并积极实施复苏策略以保护创伤患者的肾功能。

病例描述

一名3岁男孩在车祸后出现急性肾损伤。发生了多器官功能障碍,进行了剖腹手术和肝裂伤修复。给予了7天的连续性肾脏替代治疗、血浆置换、抗菌治疗和多器官支持。1年随访显示无器官功能障碍。

结论

本病例报告描述了一名因创伤导致急性肾损伤患儿的治疗过程,强调了提高对创伤性急性肾损伤风险快速识别的必要性,并积极实施复苏策略以保护创伤患者的肾功能。必要时应考虑及时进行连续性肾脏替代治疗以预防不良后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11982988/d73f27318960/tp-14-03-494-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11982988/d73f27318960/tp-14-03-494-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78cf/11982988/d73f27318960/tp-14-03-494-f1.jpg

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本文引用的文献

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How I Treat Rhabdomyolysis-Induced AKI?我如何治疗横纹肌溶解症诱发的急性肾损伤?
Clin J Am Soc Nephrol. 2024 Mar 1;19(3):385-387. doi: 10.2215/CJN.0000000000000372. Epub 2023 Nov 7.
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Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials.危重症患者连续性肾脏替代治疗的抗凝选择:系统评价和网络荟萃分析的随机对照试验。
Crit Care. 2023 Jun 7;27(1):222. doi: 10.1186/s13054-023-04519-1.
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Management of regional citrate anticoagulation for continuous renal replacement therapy: guideline recommendations from Chinese emergency medical doctor consensus.
连续肾脏替代治疗中局部枸橼酸抗凝管理:中国急诊医师共识的指南推荐。
Mil Med Res. 2023 May 29;10(1):23. doi: 10.1186/s40779-023-00457-9.
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Prevalence and Mortality of Post-traumatic Acute Kidney Injury in Children; a Systematic Review and Meta-analysis.儿童创伤后急性肾损伤的患病率与死亡率:一项系统评价与荟萃分析
Arch Acad Emerg Med. 2022 Nov 7;10(1):e89. doi: 10.22037/aaem.v10i1.1660. eCollection 2022.
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Myoglobin clearance with continuous veno-venous hemodialysis using high cutoff dialyzer versus continuous veno-venous hemodiafiltration using high-flux dialyzer: a prospective randomized controlled trial.高截留系数在线血液透析与高通量在线血液透析滤过清除肌红蛋白的前瞻性随机对照研究。
Crit Care. 2020 Nov 11;24(1):644. doi: 10.1186/s13054-020-03366-8.
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Acute kidney injury after brain injury: does it exist?脑损伤后的急性肾损伤:它存在吗?
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Immunopathophysiology of trauma-related acute kidney injury.创伤相关急性肾损伤的免疫病理生理学。
Nat Rev Nephrol. 2021 Feb;17(2):91-111. doi: 10.1038/s41581-020-00344-9. Epub 2020 Sep 21.
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Pharmacological interventions for preventing clotting of extracorporeal circuits during continuous renal replacement therapy.连续肾脏替代治疗期间预防体外循环凝血的药理学干预措施。
Cochrane Database Syst Rev. 2020 Mar 13;3(3):CD012467. doi: 10.1002/14651858.CD012467.pub2.
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