Poza María, Martin-Muñoz Alejandro, López-Pereira Patricia, Figaredo Gloria, Zamanillo Irene, Íñiguez Rodrigo, Oliveira Ana Carla, Baumann Tycho, Rodríguez-Izquierdo Antonia, Grande Carlos, Sarandeses Pilar, Revilla Enrique, Cortés Montserrat, Ayala Rosa, Calbacho María, Martínez Joaquín, Barrio Santiago, Jiménez-Ubieto Ana
Department of Hematology, Hospital Universitario 12 de Octubre, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), CNIO, CIBERONC, 28041 Madrid, Spain.
Altum Sequencing Co., 28005 Madrid, Spain.
Cancers (Basel). 2025 Mar 21;17(7):1065. doi: 10.3390/cancers17071065.
: This study aimed to determine whether interim PET/CT (iPET) scans could identify follicular lymphoma (FL) patients at high risk of relapse following first-line therapy. : A total of 117 FL patients who underwent iPET scans were included, with responses interpreted using the Deauville score (DS). Progression-free survival (PFS) was evaluated over a median follow-up of 34 months. : Overall, 34% of patients were classified as iPET (+), with significantly worse estimated 5-year PFS compared to iPET (-) patients (34% vs. 76%, hazard ratio 4.3, < 0.001). Multivariate analysis confirmed iPET (+) as an independent predictor of PFS. : Interim PET results are significant predictors of PFS in FL first-line therapy and could inform response-adapted treatment strategies.
本研究旨在确定中期正电子发射断层扫描/计算机断层扫描（iPET）能否识别一线治疗后有高复发风险的滤泡性淋巴瘤（FL）患者。共纳入117例行iPET扫描的FL患者，采用多维尔评分（DS）对反应进行解读。在中位随访34个月期间评估无进展生存期（PFS）。总体而言，34%的患者被归类为iPET（+），与iPET（-）患者相比，估计5年PFS显著更差（34%对76%，风险比4.3，<0.001）。多变量分析证实iPET（+）是PFS的独立预测因素。中期PET结果是FL一线治疗中PFS的重要预测因素，可为适应性治疗策略提供依据。
