Chun Jeana, Scholl Ashley R, Crimmins Jennifer, Schneider Michelle M, Selim M Angelica, Al-Rohil Rami N
School of Medicine, Duke University, Durham, NC 27710, USA.
Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Cancers (Basel). 2025 Apr 4;17(7):1218. doi: 10.3390/cancers17071218.
Diagnostic uncertainty for ambiguous lesions that fall on the spectrum between nevi and melanoma remains a significant challenge and can have consequences for patient management.
This study aimed to compare the diagnostic utility of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry to molecular testing (FISH and SNP array) in 34 diagnostically challenging melanocytic lesions and 9 non-diagnostically challenging melanomas.
We conclude that while PRAME immunohistochemistry demonstrates high specificity (96.2%) in diagnostically challenging melanocytic lesions, its low sensitivity (12.5%) suggests that it should not replace histopathological evaluation in rendering the final diagnosis.
These findings suggest that PRAME may serve as a useful adjunct in the diagnostic workup, particularly due to its high negative predictive value, but should be used in conjunction with other established diagnostic modalities.
对于处于痣和黑色素瘤之间谱系的不明确病变，诊断不确定性仍然是一项重大挑战，并且可能对患者管理产生影响。
本研究旨在比较黑色素瘤优先表达抗原（PRAME）免疫组化与分子检测（FISH和SNP阵列）在34例具有诊断挑战性的黑素细胞病变和9例无诊断挑战性的黑色素瘤中的诊断效用。
我们得出结论，虽然PRAME免疫组化在具有诊断挑战性的黑素细胞病变中显示出高特异性（96.2%），但其低敏感性（12.5%）表明在做出最终诊断时它不应取代组织病理学评估。
这些发现表明PRAME可能作为诊断检查中的有用辅助手段，特别是由于其高阴性预测值，但应与其他既定的诊断方法结合使用。
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