生物标志物的进展及器官衰老的诊断意义

Advances in biomarkers and diagnostic significance of organ aging.

作者信息

Chen Yulin, Li Jiadong, Liu Xinru, Geng Zhen, Xu Ke, Su Jiacan

机构信息

Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.

Organoid Research Center, Shanghai University, Shanghai 200444, China.

出版信息

Fundam Res. 2023 Apr 9;5(2):683-696. doi: 10.1016/j.fmre.2023.03.009. eCollection 2025 Mar.

DOI:10.1016/j.fmre.2023.03.009

PMID:40242549

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11997494/

Abstract

A complete understanding of aging is a critical first step in treating age-related diseases and postponing aging dysfunction in the context of an aging global population. Aging in organisms is driven by related molecular alterations that gradually occur in many organs. There has previously been a wealth of knowledge of how cells behave as they age, but when aging is investigated as a disease, the discovery and selection of aging biomarkers and how to diagnose the aging of the organism are crucial. Here, we provide a summary of the state of the field and suggest future potential routes for research on organ senescence markers. We reviewed research on biomarkers of risk of aging from the perspective of organ aging and summarized the biomarkers currently used on three scales. We emphasize that the combination of traditional markers with emerging multifaceted biomarkers may be a better way to diagnose age-related diseases.

摘要

在全球人口老龄化的背景下，全面了解衰老过程是治疗与年龄相关疾病和延缓衰老功能障碍的关键第一步。生物体的衰老由许多器官中逐渐发生的相关分子变化驱动。此前，对于细胞衰老时的行为已有丰富的认识，但当将衰老作为一种疾病进行研究时，衰老生物标志物的发现与筛选以及如何诊断生物体的衰老至关重要。在此，我们总结了该领域的现状，并提出了未来器官衰老标志物研究的潜在途径。我们从器官衰老的角度回顾了衰老风险生物标志物的研究，并总结了目前在三个层面上使用的生物标志物。我们强调，将传统标志物与新兴的多层面生物标志物相结合可能是诊断与年龄相关疾病的更好方法。