Tuberculosis (TB) remains a major health challenge in India, with a significant burden among tribal populations. These communities experience disproportionately high TB prevalence due to factors such as geographical isolation, socio-economic challenges, and cultural practices, further worsened by malnutrition, overcrowded living conditions, and limited awareness. Despite efforts under national programs aimed at eliminating TB, various socio-cultural and logistical barriers continue to impede progress in tribal regions. This discussion underscores the need for culturally sensitive healthcare approaches to effectively address these challenges. A structured framework focusing on cultural awareness, knowledge, sensitivity, and competence is recommended to develop tailored interventions. Key strategies include training healthcare workers to understand tribal customs, creating accessible educational materials, involving tribal leaders in stigma-reduction efforts, and integrating traditional practices with modern healthcare systems. To achieve impactful outcomes, it is essential to enhance healthcare infrastructure, implement customized awareness campaigns, address underlying socio-economic issues, and leverage technology for better outreach and adherence. Real-world examples from tribal regions illustrate both advancements and ongoing gaps in TB care. A collaborative effort among various stakeholders is crucial to bridge healthcare disparities and empower tribal communities in the fight against TB, ultimately contributing to the national goal of its elimination while improving the overall well-being of these populations.