Aderinto Nicholas, Olatunji Gbolahan, Kokori Emmanuel, Ogieuhi Ikponmwosa Jude, Yusuf Ismaila Ajayi, Egbunu Emmanuel, Ukoaka Bonaventure Michael, Babalola Adetola Emmanuel, Adefusi Temiloluwa Oluwakorede, Aboje John Ehi, Moradeyo Abdulrahmon
Department of Medicine and Surgery, Ladoke Akintola University of Technology, Ogbomoso, Nigeria.
Department of Medicine and Surgery, University of Ilorin, Ilorin, Nigeria.
Discov Ment Health. 2025 Apr 17;5(1):56. doi: 10.1007/s44192-025-00189-3.
The recent surge of COVID-19 cases has raised concerns about its potential long-term effects on cognitive function. This review explores the growing body of research investigating the link between COVID-19 infection and cognitive impairment. Studies employing observational, longitudinal, and case-control designs reveal a concerning prevalence of cognitive impairment in survivors, affecting domains like attention, memory, executive function, and processing speed. The persistence of these deficits for months after the initial infection highlights the potential for long-term consequences. While the precise mechanisms remain under investigation, potential contributing factors include neuroinflammation, hypoxia, and psychological effects. Limitations within the current research landscape necessitate further investigation into the long-term trajectory of cognitive decline, the potential for intervention and recovery, and the role of vaccination in mitigating these effects. Understanding the multifaceted nature of this issue is crucial for developing effective strategies to ensure optimal cognitive health outcomes for COVID-19 survivors.
近期新冠病毒感染病例的激增引发了人们对其可能对认知功能产生的长期影响的担忧。本综述探讨了越来越多关于研究新冠病毒感染与认知障碍之间联系的研究。采用观察性、纵向和病例对照设计的研究表明,幸存者中认知障碍的患病率令人担忧,影响到注意力、记忆力、执行功能和处理速度等领域。在初次感染后的数月里,这些缺陷持续存在,凸显了长期后果的可能性。虽然确切机制仍在研究中,但潜在的促成因素包括神经炎症、缺氧和心理影响。当前研究领域的局限性使得有必要进一步研究认知衰退的长期轨迹、干预和恢复的可能性,以及疫苗接种在减轻这些影响方面的作用。了解这个问题的多面性对于制定有效策略以确保新冠病毒幸存者获得最佳认知健康结果至关重要。