Prasad Monisha, Balasubramaniam Lithesh M, Priya Malareni D L, Varun B R, Sekar Ramya
Department of Community Medicine, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
PG Department of Biochemistry, Auxilium College (Autonomous), Vellore, Tamil Nadu, India.
J Oral Maxillofac Pathol. 2025 Jan-Mar;29(1):41-49. doi: 10.4103/jomfp.jomfp_36_25. Epub 2025 Mar 28.
Rose species that are well-known for their therapeutic qualities include , and . The study employs assays and molecular docking to investigate their phytochemical composition and antioxidant properties.
Phytochemicals were detected in flower petals of , and that had been extracted using methanol. Ascorbic acid was utilised as the standard reference for assessing antioxidant activity and its hydrogen peroxide scavenging potential. Superoxide dismutase (SOD) interactions with berberine, emodin, and limonene were assessed by molecular docking using PyRx software.
Various beneficial substances were found in all species according to phytochemical investigation. Among the three Rosa species, demonstrated the highest antioxidant activity, followed by and . Docking studies demonstrated that berberine and emodin had substantial binding affinity with SOD. The extracts showed strong antioxidant properties, suggesting that they could be used as naturally occurring antioxidants.
, and show promise as medicinal plants and have strong antioxidant properties. The results validate the development of these rose species as naturally occurring antioxidants for the treatment of ailments related with oxidative stress.
以其治疗特性而闻名的玫瑰品种包括……。本研究采用……分析和……分子对接来研究它们的植物化学成分和抗氧化特性。
在使用甲醇提取的……、……和……的花瓣中检测植物化学物质。抗坏血酸用作评估抗氧化活性及其过氧化氢清除潜力的标准参考。使用PyRx软件通过分子对接评估超氧化物歧化酶(SOD)与小檗碱、大黄素和柠檬烯的相互作用。
根据植物化学研究,在所有品种中都发现了各种有益物质。在这三个蔷薇属物种中,……表现出最高的抗氧化活性,其次是……和……。对接研究表明,小檗碱和大黄素与SOD具有显著的结合亲和力。提取物显示出很强的抗氧化特性,表明它们可用作天然抗氧化剂。
……、……和……有望成为药用植物并具有很强的抗氧化特性。结果证实了将这些玫瑰品种开发为用于治疗与氧化应激相关疾病的天然抗氧化剂的可行性。