探索针对葡萄球菌丝氨酸蛋白酶样蛋白A的IgE作为迟发性哮喘的表型标志物
Exploration of IgE Specific to Staphylococcal Serine Protease-Like Protein A as a Phenotypic Marker in Late-Onset Asthma.
作者信息
Won Ha-Kyeong, Lee Jiwon, Park Kyung Eun, Choi Jun-Pyo, Song Woo-Jung
机构信息
Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Korea.
Institute of Allergy and Clinical Immunology, Asan Medical Research Center, Seoul, Korea.
出版信息
Lung. 2025 Apr 18;203(1):56. doi: 10.1007/s00408-025-00810-w.
PURPOSE
Staphylococcus aureus (SA) secretes pro-allergic molecules, including staphylococcal enterotoxins (SEs) and serine protease-like proteins (Spls). While IgE sensitization to SE has been relatively well documented in relation to severe eosinophilic late-onset asthma, the clinical implications of IgE sensitization to Spls remain unclear. We explored the clinical relevance of Spl-IgE in late-onset asthmatics.
METHODS
Adults with late-onset asthma (onset age ≥ 40 years) were prospectively enrolled. Demographic and clinical characteristics were assessed, and serum levels of total IgE, SE-IgE, and SplA-IgE were measured. Nasal swabs were obtained to assess SA colonization.
RESULTS
Among 109 participants, SplA-IgE levels were significantly associated with blood eosinophilia, total IgE, SE-IgE sensitization, and male sex, but not with SA colonization, asthma severity, or lung function.
CONCLUSION
Sensitization to SplA-IgE may indicate a type 2 inflammatory phenotype, but its role in asthma warrants further investigation.
目的
金黄色葡萄球菌（SA）分泌促过敏分子，包括葡萄球菌肠毒素（SEs）和丝氨酸蛋白酶样蛋白（Spls）。虽然在严重嗜酸性粒细胞性迟发性哮喘方面，IgE对SE的致敏作用已有相对充分的文献记载，但IgE对Spls致敏的临床意义仍不明确。我们探讨了Spl-IgE在迟发性哮喘患者中的临床相关性。
方法
前瞻性纳入迟发性哮喘（发病年龄≥40岁）的成年人。评估人口统计学和临床特征，并检测血清总IgE、SE-IgE和SplA-IgE水平。采集鼻拭子以评估SA定植情况。
结果
在109名参与者中，SplA-IgE水平与血液嗜酸性粒细胞增多、总IgE、SE-IgE致敏以及男性显著相关，但与SA定植、哮喘严重程度或肺功能无关。
结论
对SplA-IgE的致敏可能表明2型炎症表型，但其在哮喘中的作用值得进一步研究。
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