Meyerhoff W L, Gates G A, Montalbo P J
Laryngoscope. 1977 Apr;87(4 Pt 1):483-92. doi: 10.1288/00005537-197704000-00003.
Opportunistic infections of the external auditory canal or the middle ear due to Pseudomonas aeruginosa occurring in patients with low resistance to infection have a 35 percent mortality rate. Once the process extends into the pneumatized temporal bone, eradication becomes more difficult and the mortality rate increases to 72 percent because of the high incidence of involvement of cranial nerves, adjacent intracranial vessels, and meningitis. Treatment is directed towards the underlying condition, administration of systemic carbenicillin and gentamicin, topical colistin therapy, and judicious surgical debridement. Pseudomonas vaccine may be of help. Fifteen cases are presented. Nine follow the pattern of malignant external otitis and six began as a primary acute otitis media.
铜绿假单胞菌引起的外耳道或中耳机会性感染发生在抗感染能力低的患者中，死亡率为35%。一旦病变扩展到气化的颞骨，根除就变得更加困难，由于颅神经、相邻颅内血管受累及脑膜炎的发生率高，死亡率增至72%。治疗针对基础疾病，给予全身性羧苄青霉素和庆大霉素、局部用多粘菌素治疗以及明智的外科清创术。铜绿假单胞菌疫苗可能有帮助。本文报告15例。9例呈恶性外耳道炎模式，6例起病为原发性急性中耳炎。
