Ellis Hugh Logan, Dunnell Liam, Eyres Ruth, Whitney Julie, Jennings Cara, Wilson Dan, Tippett Jane, Stein Dan F, Teo James, Ibrahim Zina, Rockwood Kenneth
King's College London, Department of Biostatistics & Health Informatics, Social Genetic and Developmental Psychiatry Centre, Memory Lane, Southwark, London, SE5 8AF, UK.
Dalhousie University Ringgold Standard Institution,Department of Medicine, Suite 1421-5955, Veterans' Memorial Lane, Halifax, Nova Scotia, B3H 4R2, Canada.
Age Ageing. 2025 Mar 28;54(4). doi: 10.1093/ageing/afaf093.
Emergency departments (EDs) in England are under significant strain, with increasing attendances and extended wait times, affecting frail older adults. The clinical frailty scale (CFS) has been implemented as a tool to assess frailty in ED settings, but its reliability and predictive accuracy as a screening tool remain debated.
To evaluate the use and variability of the CFS in EDs and its association with patient outcomes, including discharge rates, length of stay, readmission and mortality.
A retrospective cohort study of ED attendances at two London (UK) hospitals from 2017 to 2021. Data included CFS scores, demographics, clinical observations and outcomes. Comparative statistics, logistic regression, Cox proportional hazards models and competing risk regression were applied to examine CFS predictive validity.
In a sample of 123 324 ED visits, CFS scores strongly correlated with adverse outcomes: e.g. for long-term mortality (n = 33 475, events = 8871), each CFS single-point increase was associated with a 25% increase in mortality risk (95% CI 1.23-1.26). CFS scores varied significantly between raters and across visits, median difference two levels (interquartile range 1-3). Intraclass correlation coefficient analysis showed that 33.1% of CFS score differences was attributable to between-patient differences, 15.4% to inter-rater differences, with 51.5% residual variance from non-frailty factors, such as acute illness severity.
The CFS is associated with crucial patient outcomes in the ED. Inter-rater variability and potentially confounding factors can limit its consistency. Automation to enhance CFS score reliability should be explored as a means to support proactive management.
英国的急诊科面临巨大压力,就诊人数不断增加,等待时间延长,这对体弱的老年人产生了影响。临床衰弱量表(CFS)已被用作评估急诊科患者衰弱程度的工具,但其作为筛查工具的可靠性和预测准确性仍存在争议。
评估CFS在急诊科的使用情况和变异性,及其与患者结局的关联,包括出院率、住院时间、再入院率和死亡率。
对英国伦敦两家医院2017年至2021年急诊科就诊情况进行回顾性队列研究。数据包括CFS评分、人口统计学信息、临床观察结果和结局。应用比较统计、逻辑回归、Cox比例风险模型和竞争风险回归来检验CFS的预测效度。
在123324次急诊科就诊样本中,CFS评分与不良结局密切相关:例如,对于长期死亡率(n = 33475,事件数 = 8871),CFS每增加一个单点,死亡风险增加25%(95% CI 1.23 - 1.26)。评分者之间以及不同就诊之间的CFS评分差异显著,中位数差异为两个等级(四分位间距1 - 3)。组内相关系数分析表明,CFS评分差异的33.1%可归因于患者之间的差异,15.4%归因于评分者之间的差异,51.5%的剩余方差来自非衰弱因素,如急性疾病严重程度。
CFS与急诊科患者的关键结局相关。评分者之间的变异性和潜在的混杂因素可能会限制其一致性。应探索自动化以提高CFS评分的可靠性,作为支持积极管理的一种手段。