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从儿科患者中分离出的尿路病原体的抗生素耐药模式:一项多中心研究。

Patterns of antibiotic resistance in uropathogens isolated from pediatric patients: A multicenter study.

作者信息

Almatroudi Zeyad A, Almazrou Abdullah M, Aljomoai Abdullah H, Alsulami Zaid M, Alotaibi Abdulaziz M, Almutairi Abdulmohsen A, El-Saed Aiman, Alsehli Faisal A, Alshamrani Majid M

机构信息

From the College of Medicine (Almatroudi, Almazrou, Aljomoai, Alsulami, Alotaibi, Almutairi, Alsehli), King Saud bin Abdulaziz University for Health Sciences, from the Department of Neonatal Intensive Care (Alsehli); and from the Department of Infection Prevention and Control (El-Saed, Alshamrani), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2025 Apr;46(4):418-424. doi: 10.15537/smj.2025.46.4.20241083.

Abstract

OBJECTIVES

To evaluate the antibiotic resistance patterns in common uropathogens isolated from pediatric patients.

METHODS

This was a retrospective chart review on the uropathogens causing first-time, community-acquired, symptomatic urinary tract infection (UTI). The data for this study was collected from one tertiary care hospital and 4 primary care centers in Riyadh, Saudi Arabia, with data spanning from 2017-2022. Diagnosis of UTIs was in line with the guidelines of the American Academy of Pediatrics.

RESULTS

Isolates were gathered from 610 patients, 101 (16.6%) of whom were male and 509 (83.4%) were female. The 3 most common species isolated were (; 50.5% in males and 82.7% in females), (; 28.7% males and 10.4% females), and then (5.9% males and 2.9% in females). was more prevalent in females than in males (<0.001). Multidrugresistant was isolated more often from males than in females (39.2% versus 23.5%, =0.014). A similar but non-significant trend was observed in multidrug-resistant (48.1% versus 30.8%, =0.128), extended-spectrum beta-lactamase (ESBL) producing (13.7% versus 11.9%, =0.701), and ESBL-producing (18.5% versus 7.7%, =0.151).

CONCLUSION

Our study indicates that surveillance of uropathogen resistance should differentiate between isolates gathered from male and female patients. This study also indicates a possible increase in ESBL-producing isolates, and an increase in multidrug-resistant isolates.

摘要

目的

评估从儿科患者中分离出的常见尿路病原体的抗生素耐药模式。

方法

这是一项对引起首次社区获得性症状性尿路感染(UTI)的尿路病原体的回顾性图表审查。本研究的数据收集自沙特阿拉伯利雅得的一家三级护理医院和4家初级护理中心,数据涵盖2017年至2022年。UTI的诊断符合美国儿科学会的指南。

结果

从610名患者中分离出病原体,其中101名(16.6%)为男性,509名(83.4%)为女性。分离出的3种最常见菌种为(男性中占50.5%,女性中占82.7%),(男性中占28.7%,女性中占10.4%),然后是(男性中占5.9%,女性中占2.9%)。在女性中比在男性中更普遍(<0.001)。多重耐药在男性中比在女性中更常分离到(39.2%对23.5%,=0.014)。在多重耐药(48.1%对30.8%,=0.128)、产超广谱β-内酰胺酶(ESBL)的(13.7%对11.9%,=0.701)和产ESBL的(18.5%对7.7%,=0.151)中观察到类似但不显著的趋势。

结论

我们的研究表明,对尿路病原体耐药性的监测应区分从男性和女性患者中分离出的菌株。本研究还表明产ESBL的菌株可能增加,以及多重耐药菌株增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c30/12010488/4d5b26325dc0/smj-46-4-418_1.jpg

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Patterns of antibiotic resistance in uropathogens isolated from pediatric patients: A multicenter study.
Saudi Med J. 2025 Apr;46(4):418-424. doi: 10.15537/smj.2025.46.4.20241083.

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Community-acquired urinary tract infections in children: Resistance patterns of uropathogens in a tertiary care center in Saudi Arabia.
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