从儿科患者中分离出的尿路病原体的抗生素耐药模式：一项多中心研究。

Patterns of antibiotic resistance in uropathogens isolated from pediatric patients: A multicenter study.

作者信息

Almatroudi Zeyad A, Almazrou Abdullah M, Aljomoai Abdullah H, Alsulami Zaid M, Alotaibi Abdulaziz M, Almutairi Abdulmohsen A, El-Saed Aiman, Alsehli Faisal A, Alshamrani Majid M

机构信息

From the College of Medicine (Almatroudi, Almazrou, Aljomoai, Alsulami, Alotaibi, Almutairi, Alsehli), King Saud bin Abdulaziz University for Health Sciences, from the Department of Neonatal Intensive Care (Alsehli); and from the Department of Infection Prevention and Control (El-Saed, Alshamrani), King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

出版信息

Saudi Med J. 2025 Apr;46(4):418-424. doi: 10.15537/smj.2025.46.4.20241083.

DOI:10.15537/smj.2025.46.4.20241083

PMID:40254313

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12010488/

Abstract

OBJECTIVES

To evaluate the antibiotic resistance patterns in common uropathogens isolated from pediatric patients.

METHODS

This was a retrospective chart review on the uropathogens causing first-time, community-acquired, symptomatic urinary tract infection (UTI). The data for this study was collected from one tertiary care hospital and 4 primary care centers in Riyadh, Saudi Arabia, with data spanning from 2017-2022. Diagnosis of UTIs was in line with the guidelines of the American Academy of Pediatrics.

RESULTS

Isolates were gathered from 610 patients, 101 (16.6%) of whom were male and 509 (83.4%) were female. The 3 most common species isolated were (; 50.5% in males and 82.7% in females), (; 28.7% males and 10.4% females), and then (5.9% males and 2.9% in females). was more prevalent in females than in males (<0.001). Multidrugresistant was isolated more often from males than in females (39.2% versus 23.5%, =0.014). A similar but non-significant trend was observed in multidrug-resistant (48.1% versus 30.8%, =0.128), extended-spectrum beta-lactamase (ESBL) producing (13.7% versus 11.9%, =0.701), and ESBL-producing (18.5% versus 7.7%, =0.151).

CONCLUSION

Our study indicates that surveillance of uropathogen resistance should differentiate between isolates gathered from male and female patients. This study also indicates a possible increase in ESBL-producing isolates, and an increase in multidrug-resistant isolates.

摘要

目的

评估从儿科患者中分离出的常见尿路病原体的抗生素耐药模式。

方法

这是一项对引起首次社区获得性症状性尿路感染（UTI）的尿路病原体的回顾性图表审查。本研究的数据收集自沙特阿拉伯利雅得的一家三级护理医院和4家初级护理中心，数据涵盖2017年至2022年。UTI的诊断符合美国儿科学会的指南。

结果

从610名患者中分离出病原体，其中101名（16.6%）为男性，509名（83.4%）为女性。分离出的3种最常见菌种为（男性中占50.5%，女性中占82.7%），（男性中占28.7%，女性中占10.4%），然后是（男性中占5.9%，女性中占2.9%）。在女性中比在男性中更普遍（<0.001）。多重耐药在男性中比在女性中更常分离到（39.2%对23.5%，=0.014）。在多重耐药（48.1%对30.8%，=0.128）、产超广谱β-内酰胺酶（ESBL）的（13.7%对11.9%，=0.701）和产ESBL的（18.5%对7.7%，=0.151）中观察到类似但不显著的趋势。