Port Helena, Coppers Birte, Tragl Sonja, Manger Eva, Niemiec Lisa M, Bayat Sara, Simon David, Fagni Filippo, Corte Giulia, Bay-Jensen Anne-Christine, Tascilar Koray, Hueber Axel J, Schmidt Katja G, Schönau Verena, Sticherling Michael, Heinrich Simon, Leyendecker Sigrid, Bohr Daniela, Schett Georg, Kleyer Arnd, Holm Nielsen Signe, Liphardt Anna-Maria
University of Copenhagen, Copenhagen, Denmark.
Nordic Bioscience, Herlev, Denmark.
Sci Rep. 2025 Apr 21;15(1):13656. doi: 10.1038/s41598-025-98395-0.
Inflammatory arthritis, including rheumatoid arthritis and psoriatic arthritis, is characterized by physical function impairment. This becomes apparent even before arthritis onset, as in psoriasis (PsO). Chronic inflammation triggers an accelerated remodeling of the extracellular matrix (ECM), resulting in released ECM fragments detectable in blood. We aimed to investigate levels of blood-based ECM biomarkers in patients with RA, PsA, PsO, and healthy controls and to explore the association of ECM biomarkers with hand function impairments. Patients with RA (n = 85), PsA (n = 115), PsO (n = 102) and controls (n = 110) were included in this cross-sectional study. ECM catabolic (C1M, C2M, C3M, C4M, PRO-C4, C6M, ARG), formation (PRO-C1, PRO-C3, PRO-C6) and inflammation biomarkers (VICM) were measured in serum from all patients. Objective hand function (fine motor skills (Moberg-Picking-Up Test), isometric grip strength (dynamometer) and patient-perceived hand function (Michigan Hand Questionnaire (MHQ)) were assessed. Patients with RA and PsA received treatment with disease-modifying anti-rheumatic drugs. VICM levels were higher in RA, PsA, and PsO than in controls (p < 0.0001). PsA and PsO showed higher C4M levels compared to controls (p < 0.0001, p < 0.0001), while C6M was lower in patients with RA, PsA and PsO than in controls (p < 0.0001, p < 0.001, p < 0.01). PsO presented with higher levels of C1M compared to controls and to RA (p < 0.001 and p < 0.0001). PRO-C6 correlated negatively with MHQ (ρ = -0.39, p < 0.01) and grip strength (ρ = -0.31, p < 0.05) in PsO, while only weak correlations were observed between biomarkers and hand function scores for RA and PsA patients (all ρ < ± 0.2-0.3). Patients with RA, PsA, and PsO showed significant alterations in ECM remodeling biomarkers. Especially PsA and PsO had higher levels of inflammatory biomarkers compared to RA and controls, likely due to modulation by treatment. Predominantly in PsO, ECM formation biomarkers were associated with hand function impairments.
包括类风湿性关节炎和银屑病关节炎在内的炎性关节炎，其特征为身体功能受损。这甚至在关节炎发作之前就已显现，如在银屑病（PsO）中。慢性炎症引发细胞外基质（ECM）加速重塑，导致血液中可检测到释放的ECM片段。我们旨在研究类风湿性关节炎（RA）、银屑病关节炎（PsA）、银屑病（PsO）患者及健康对照者血液中基于ECM的生物标志物水平，并探讨ECM生物标志物与手部功能障碍的关联。本横断面研究纳入了RA患者（n = 85）、PsA患者（n = 115）、PsO患者（n = 102）和对照者（n = 110）。检测了所有患者血清中的ECM分解代谢生物标志物（C1M、C2M、C3M、C4M、PRO - C4、C6M、ARG）、形成生物标志物（PRO - C1、PRO - C3、PRO - C6）和炎症生物标志物（VICM）。评估了客观手部功能（精细运动技能（莫伯格拾物试验）、等长握力（测力计））以及患者自我感知的手部功能（密歇根手部问卷（MHQ））。RA和PsA患者接受改善病情抗风湿药物治疗。RA、PsA和PsO患者的VICM水平高于对照者（p < 0.0001）。与对照者相比，PsA和PsO患者的C4M水平更高（p < 0.0001，p < 0.0001），而RA、PsA和PsO患者的C6M水平低于对照者（p < 0.0001，p < 0.001，p < 0.01）。与对照者及RA患者相比，PsO患者的C1M水平更高（p < 0.001和p < 0.0001）。在PsO患者中，PRO - C6与MHQ（ρ = -0.39，p < 0.01）和握力（ρ = -0.31，p < 0.05）呈负相关，而在RA和PsA患者中，生物标志物与手部功能评分之间仅观察到弱相关性（所有ρ < ±0.2 - 0.3）。RA、PsA和PsO患者的ECM重塑生物标志物有显著改变。尤其是PsA和PsO患者的炎症生物标志物水平高于RA患者和对照者，这可能是由于治疗的调节作用。主要在PsO患者中，ECM形成生物标志物与手部功能障碍相关。
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