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GIT ArfGAP2: A Cytoskeletal Safeguard in Podocytes: Suppressing Rac1 to Combat Glomerular Injury.

作者信息

Ishibe Shuta, Tian Xuefei

机构信息

Yale University School of Medicine, New Haven, Connecticut.

出版信息

J Am Soc Nephrol. 2025 Jun 1;36(6):1005-1007. doi: 10.1681/ASN.0000000707. Epub 2025 Apr 18.

Abstract
摘要

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本文引用的文献

1
Rac1 Suppression by the Focal Adhesion Protein GIT ArfGAP2 and Podocyte Protection.
J Am Soc Nephrol. 2025 Jun 1;36(6):1088-1104. doi: 10.1681/ASN.0000000614. Epub 2025 Feb 28.
2
Inhibition of Endocytosis of Clathrin-Mediated Angiotensin II Receptor Type 1 in Podocytes Augments Glomerular Injury.
J Am Soc Nephrol. 2019 Dec;30(12):2307-2320. doi: 10.1681/ASN.2019010053. Epub 2019 Sep 11.
3
The single-cell transcriptomic landscape of early human diabetic nephropathy.
Proc Natl Acad Sci U S A. 2019 Sep 24;116(39):19619-19625. doi: 10.1073/pnas.1908706116. Epub 2019 Sep 10.
5
Rac1 activation in podocytes induces the spectrum of nephrotic syndrome.
Kidney Int. 2017 Aug;92(2):349-364. doi: 10.1016/j.kint.2017.03.010. Epub 2017 May 6.
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Targeting the podocyte cytoskeleton: from pathogenesis to therapy in proteinuric kidney disease.
Nephrol Dial Transplant. 2016 Oct;31(10):1577-83. doi: 10.1093/ndt/gfw021. Epub 2016 Mar 10.
7
ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling.
J Clin Invest. 2013 Aug;123(8):3243-53. doi: 10.1172/JCI69134. Epub 2013 Jul 8.
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Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease.
J Clin Invest. 2012 Feb;122(2):674-92. doi: 10.1172/JCI60070. Epub 2012 Jan 17.
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Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels.
Sci Signal. 2010 Oct 26;3(145):ra77. doi: 10.1126/scisignal.2001200.
10
Actin up: regulation of podocyte structure and function by components of the actin cytoskeleton.
Trends Cell Biol. 2007 Sep;17(9):428-37. doi: 10.1016/j.tcb.2007.06.006. Epub 2007 Sep 4.

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