Hellebrekers L J, Slappendel R J, van den Brom W E
Am J Vet Res. 1985 Jul;46(7):1460-2.
Regulation of blood coagulation was studied in 12 dogs, using subcutaneous administration of sodium heparin. Dosage of heparin needed to achieve the desired 1.5- to 2.5-fold increase in the activated partial thromboplastin time (APTT) was 250 to 500 IU/kg of body weight. Increased APTT lasted less than 6 hours. Repeated heparin administration, using the lowest dosage (250 IU/kg) every 6 hours, induced an unacceptable prolongation of clotting times during the first 2 days of treatment. Prolonged administration at a dosage of 200 IU/kg every 6 hours adequately maintained the desired hypocoagulative state initially; after 2 days, however, the prolonged APTT steadily decreased. The decreasing effect was proportionate to a decrease in plasma antithrombin III (AT III). To sustain a correctly balanced hypocoagulative state from prolonged subcutaneous administration of heparin, APTT values should be determined regularly to monitor therapy. In addition, transfusion of AT III-rich donor plasma may be necessary when low plasma AT III reduces the effects of heparin.
通过皮下注射肝素钠，对12只犬的血液凝固调节进行了研究。使活化部分凝血活酶时间（APTT）达到期望的1.5至2.5倍增加所需的肝素剂量为250至500 IU/kg体重。APTT增加持续时间不到6小时。每6小时重复给予最低剂量（250 IU/kg）的肝素，在治疗的前两天导致凝血时间出现不可接受的延长。每6小时以200 IU/kg的剂量长期给药，最初能充分维持期望的低凝状态；然而，2天后，延长的APTT稳步下降。下降效应与血浆抗凝血酶III（AT III）的减少成比例。为了通过长期皮下注射肝素维持正确平衡的低凝状态，应定期测定APTT值以监测治疗。此外，当血浆AT III水平降低肝素作用时，可能需要输注富含AT III的供体血浆。
