[强力霉素和葡糖胺基胞壁酰二肽对土拉菌病疫苗株抗原初次免疫反应影响的实验性多因素研究]

[Experimental multifactorial study of the effect of doxycycline and glucosaminylmuramyl dipeptide on the primary immunologic response to antigens of a tularemia vaccine strain].

作者信息

Nikitin A V, Andronova T M, Kovalenko L P, Fishman V M, Sheptovitskaia M G

出版信息

Antibiot Med Biotekhnol. 1985 May;30(5):360-4.

Abstract

The effect of the combined use of doxycycline and glucosaminylmuramyl dipeptide (GMDP) on the primary immune response to antigens of tularemia vaccine was studied on CBA male mice with the use of the multifactorial design of experiment. Antibodies to the blood serum of the immunized animals were determined by the passive hemagglutination test with the use of the tularemia antigen diagnosticum. The delayed type hypersensitivity was estimated by changes in the weight of the extremities of the experimental and control animals treated with the antigen and saline solution, respectively. The multifactorial experiments provided precise quantitative characteristics of the optimal dose-time schedule for the combined use of GMDP and doxycycline.

摘要

采用多因素实验设计，在雄性CBA小鼠上研究了强力霉素与氨基葡糖胞壁酰二肽（GMDP）联合使用对兔热病疫苗抗原初次免疫反应的影响。使用兔热病诊断抗原，通过被动血凝试验测定免疫动物血清中的抗体。通过分别用抗原和盐溶液处理的实验动物和对照动物肢体重量的变化来评估迟发型超敏反应。多因素实验提供了GMDP与强力霉素联合使用的最佳剂量-时间方案的精确定量特征。

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