Connelly J F, Connelly J M, Nevitt J R
Psychopharmacology (Berl). 1977 Jan 31;51(2):153-7. doi: 10.1007/BF00431732.
Drug-dependent learning (lack of transfer between drug states) was demonstrated and disrupted in an escape learning, forced choice T-maze task. A drug-dependent learning (DDL) group was trained to escape foot shock (0.65 mA) while in a drug (chlordiazepoxide hydrochloride) state. These rats subsequently responded randomly on non-shock test trials in the non-drug state, but continued to respond significantly (P less than 0.02) above random level when in the training drug state. Four transfer groups were also trained in the Drug state, but with a 1 kHz auditory tone simultaneously paired with foot shock. Each Transfer group received a different (0.10, 0.65, 3.5, and 4.5 mA) foot shock intensity during training. The auditory tone continued to be sounded during testing with no foot shock, and percentage correct turns, first-trial correct turns, and latency scores were significantly (P less than 0.01) different from the DDL group's performance. The results were interpreted as demonstrating that an emotionally-important auditory stimulus could initiate a memory retrieval process that could overcome a physiological state. This memory retrival process was not modified by wide variations in foot shock intensity.
在逃避学习的强迫选择T迷宫任务中证明并破坏了药物依赖性学习（药物状态之间缺乏迁移）。一个药物依赖性学习（DDL）组在处于药物（盐酸氯氮卓）状态时接受逃避足部电击（0.65毫安）的训练。这些大鼠随后在非药物状态的非电击测试试验中随机反应，但在处于训练药物状态时继续显著（P小于0.02）高于随机水平做出反应。四个迁移组也在药物状态下进行训练，但同时将1千赫的听觉音调与足部电击配对。每个迁移组在训练期间接受不同（0.10、0.65、3.5和4.5毫安）的足部电击强度。在无足部电击的测试期间继续发出听觉音调，正确转弯百分比、首次试验正确转弯和潜伏期得分与DDL组的表现显著（P小于0.01）不同。结果被解释为表明一个具有情感重要性的听觉刺激可以启动一个可以克服生理状态的记忆检索过程。这个记忆检索过程不会因足部电击强度的广泛变化而改变。
