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信使核糖核酸疫苗：基于微小核糖核酸的可控生物分布与定向佐剂作用

mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.

作者信息

Brook Byron, Goetz Morgan, Duval Valerie, Micol Romain, Dowling David J

机构信息

Precision Vaccines Program, Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.

Combined Therapeutics Incorporated, Boston, MA 02135, USA.

出版信息

Trends Immunol. 2025 May;46(5):357-360. doi: 10.1016/j.it.2025.03.004. Epub 2025 Apr 22.

DOI:10.1016/j.it.2025.03.004
PMID:40268657
Abstract

The development of ionizable mRNA-lipid nanoparticle (mRNA-LNP) nucleic acid carriers facilitated the clinical translation of the Coronavirus 2019 (COVID-19) mRNA vaccines BNT162b2 and mRNA-1273. Here, we discuss insights into rational improvements to mRNA vaccines, focusing on LNP modifications for mRNA-LNP biodistribution control, miRNA-based biodistribution control of encoded transcripts, and precision adjuvantation strategies.

摘要

可电离的信使核糖核酸-脂质纳米颗粒（mRNA-LNP）核酸载体的发展推动了2019冠状病毒病（COVID-19）mRNA疫苗BNT162b2和mRNA-1273的临床转化。在此，我们讨论对mRNA疫苗进行合理改进的见解，重点关注用于控制mRNA-LNP生物分布的LNP修饰、基于微小RNA的编码转录本生物分布控制以及精准佐剂策略。

相似文献

[1]
mRNA vaccines: miRNA-based controlled biodistribution and directed adjuvantation.

Trends Immunol. 2025-5

[2]
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70.

Sci Transl Med. 2024-7-24

[3]
An mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses.

Sci Immunol. 2025-6-6

[4]
A Basic Method for Formulating mRNA-Lipid Nanoparticle Vaccines in the Lab.

Methods Mol Biol. 2024

[5]
Enhancing the immunogenicity of lipid-nanoparticle mRNA vaccines by adjuvanting the ionizable lipid and the mRNA.

Nat Biomed Eng. 2025-2

[6]
An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant.

EBioMedicine. 2025-6-6

[7]
Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans.

ACS Nano. 2024-10-1

[8]
TLR7-Adjuvanted Ionizable Lipid Nanoparticles for mRNA Vaccine Delivery.

AAPS J. 2025-4-25

[9]
Safflower-Derived Cationic Lipid Nanoparticles: Potential Impact on the Delivery of SARS-CoV-2 MRNA Transcripts.

Arch Razi Inst. 2024-12-31

[10]
The immunogenic potential of an optimized mRNA lipid nanoparticle formulation carrying sequences from virus and protozoan antigens.

J Nanobiotechnology. 2025-3-18

本文引用的文献

[1]
The BNT162b2 mRNA vaccine demonstrates reduced age-associated T1 support and .

iScience. 2024-9-26

[2]
Blood Distribution of SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine in Humans.

ACS Nano. 2024-10-1

[3]
Adjuvantation of a SARS-CoV-2 mRNA vaccine with controlled tissue-specific expression of an mRNA encoding IL-12p70.

Sci Transl Med. 2024-7-24

[4]
The central role of natural killer cells in mediating acute myocarditis after mRNA COVID-19 vaccination.

Med. 2024-4-12

[5]
mRNAs encoding self-DNA reactive cGAS enhance the immunogenicity of lipid nanoparticle vaccines.

mBio. 2023-12-19

[6]
Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines.

Nat Nanotechnol. 2023-9

[7]
Cytokinopathy with aberrant cytotoxic lymphocytes and profibrotic myeloid response in SARS-CoV-2 mRNA vaccine-associated myocarditis.

Sci Immunol. 2023-5-12

[8]
Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals.

Commun Biol. 2023-2-17

[9]
The Future of Tissue-Targeted Lipid Nanoparticle-Mediated Nucleic Acid Delivery.

Pharmaceuticals (Basel). 2022-7-20

[10]
Liver injury after SARS-CoV-2 vaccination: Features of immune-mediated hepatitis, role of corticosteroid therapy and outcome.

Hepatology. 2022-12

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