阿替洛尔和美托洛尔药代动力学的变异性。
Variability in the pharmacokinetics of atenolol and metoprolol.
作者信息
Ledermann H, Bippi H, Boekens H, Frölich J C, Herrmann H, Schmitt-Landherr K
出版信息
Arzneimittelforschung. 1985;35(5):848-51.
18 healthy volunteers received conventional atenolol (Tenormin) 50 mg once daily and metoprolol 50 mg twice daily for 6 days in a balanced randomised cross-over fashion. There was a wash-out period of two weeks between each phase. Plasma concentrations of the drugs were measured on the last day of each phase. Comparison of the coefficients of variation showed a lower variability in the pharmacokinetics of atenolol compared to metoprolol. The clinical implications of these findings are discussed.
18名健康志愿者以平衡随机交叉方式，每日服用一次50毫克常规阿替洛尔（天诺敏），每日服用两次50毫克美托洛尔，持续6天。每个阶段之间有两周的洗脱期。在每个阶段的最后一天测量药物的血浆浓度。变异系数的比较显示，与美托洛尔相比，阿替洛尔的药代动力学变异性较低。讨论了这些发现的临床意义。
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