• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在神经性疼痛大鼠模型中，与持续性脉冲相比，使用时间动态脉冲进行脊髓刺激可实现更长时间的痛觉过敏逆转。

Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain.

作者信息

Zhu Changfang, Jeong Ki-Soo, Edhi Muhammad, Rogness Victoria, Saab Carl Y, Esteller Rosana

机构信息

Research and Development, Boston Scientific Neuromodulation, Valencia, CA, United States.

Biomedical Engineering, Cleveland Clinic Lerner Research Institute, Cleveland, OH, United States.

出版信息

Front Pain Res (Lausanne). 2025 Apr 9;6:1541078. doi: 10.3389/fpain.2025.1541078. eCollection 2025.

DOI:10.3389/fpain.2025.1541078
PMID:40270935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12014672/
Abstract

BACKGROUND

Spinal cord stimulation (SCS) utilizing time-dynamic pulses (TDPs) is an emergent field of neuromodulation that continuously and automatically modulates pulse parameters. We previously demonstrated that TDPs delivered for 60 min at paresthesia-free or minimal paresthesia amplitudes significantly reversed allodynia in a rat model of neuropathic pain. Because the anti-allodynic effect was observed to persist post-stimulation, we hypothesized that the anti-nociceptive effects of TDPs may persist longer than those of tonic stimulation.

METHODS

We extended SCS stimulation period up to 90 min and investigated the temporal dynamics of SCS-induced analgesia through PWT analysis of the aggregated data from both cohorts.

RESULTS

Both TDPs and tonic stimulation reversed paw withdrawal thresholds (PWT) to near pre-neuropathic levels within 30 min. Most TDPs exhibited significantly slower ramp-up slope (analgesia 'wash-in' rates) as compared to tonic stimulation. All TDPs showed slower wind-down slopes (analgesia 'wash-out' rates) compared to tonic, with pulse width modulation reaching significance. Extending SCS from 60 to 90 min revealed that all TDPs maintained analgesic efficacy longer than tonic stimulation, which showed significant decrease at both 75 and 90 min.

DISCUSSION

Although TDPs and tonic stimulation comparably mitigated allodynia, TDPs exhibited slower rate of wash-out, suggesting longer-lasting analgesic effects and potentially different mechanisms of action.

摘要

背景

利用时间动态脉冲（TDP）的脊髓刺激（SCS）是神经调节的一个新兴领域，可连续自动调节脉冲参数。我们之前证明，在无感觉异常或最小感觉异常幅度下给予60分钟的TDP可显著逆转神经性疼痛大鼠模型中的痛觉过敏。由于观察到刺激后抗痛觉过敏作用持续存在，我们推测TDP的抗伤害感受作用可能比强直刺激持续更长时间。

方法

我们将SCS刺激时间延长至90分钟，并通过对两个队列的汇总数据进行 paw withdrawal thresholds（PWT）分析来研究SCS诱导镇痛的时间动态。

结果

TDP和强直刺激均在30分钟内将爪部撤离阈值（PWT）逆转至接近神经病变前水平。与强直刺激相比，大多数TDP的上升斜率（镇痛“起效”率）明显较慢。与强直刺激相比，所有TDP的下降斜率（镇痛“消退”率）均较慢，脉冲宽度调制具有显著性。将SCS从60分钟延长至90分钟显示，所有TDP的镇痛效果维持时间均长于强直刺激，强直刺激在75分钟和90分钟时均显著下降。

讨论

尽管TDP和强直刺激在减轻痛觉过敏方面相当，但TDP的消退速度较慢，表明其镇痛作用持续时间更长，且作用机制可能不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/a9c504667733/fpain-06-1541078-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/004ac2675dc9/fpain-06-1541078-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/3421fa6a55b7/fpain-06-1541078-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/081856a4f661/fpain-06-1541078-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/08046ced0d9a/fpain-06-1541078-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/e1a0298de38d/fpain-06-1541078-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/a9c504667733/fpain-06-1541078-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/004ac2675dc9/fpain-06-1541078-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/3421fa6a55b7/fpain-06-1541078-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/081856a4f661/fpain-06-1541078-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/08046ced0d9a/fpain-06-1541078-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/e1a0298de38d/fpain-06-1541078-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bdde/12014672/a9c504667733/fpain-06-1541078-g006.jpg

相似文献

1
Spinal cord stimulation using time-dynamic pulses achieves longer reversal of allodynia compared to tonic pulses in a rat model of neuropathic pain.在神经性疼痛大鼠模型中，与持续性脉冲相比，使用时间动态脉冲进行脊髓刺激可实现更长时间的痛觉过敏逆转。
Front Pain Res (Lausanne). 2025 Apr 9;6:1541078. doi: 10.3389/fpain.2025.1541078. eCollection 2025.
2
Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats.脊髓刺激的时动态脉冲调制可减少大鼠的机械性痛觉过敏和自发性疼痛。
Sci Rep. 2020 Nov 23;10(1):20358. doi: 10.1038/s41598-020-77212-w.
3
A Comparison of the Effects of Burst and Tonic Spinal Cord Stimulation on Hyperalgesia and Physical Activity in an Animal Model of Neuropathic Pain.爆发性和强直性脊髓刺激对神经性疼痛动物模型中痛觉过敏和身体活动影响的比较
Anesth Analg. 2016 Apr;122(4):1178-1185. doi: 10.1213/ANE.0000000000001161. Epub 2016 Feb 8.
4
Exploratory evaluation of spinal cord stimulation with dynamic pulse patterns: a promising approach to improve stimulation sensation, coverage of pain areas, and expected pain relief.动态脉冲模式脊髓刺激的探索性评估：一种改善刺激感觉、疼痛区域覆盖范围和预期疼痛缓解效果的有前景的方法。
Front Pain Res (Lausanne). 2024 Jan 31;4:1339892. doi: 10.3389/fpain.2023.1339892. eCollection 2023.
5
Burst and Tonic Spinal Cord Stimulation Differentially Activate GABAergic Mechanisms to Attenuate Pain in a Rat Model of Cervical Radiculopathy.爆发性和强直性脊髓刺激以不同方式激活GABA能机制，减轻颈神经根病大鼠模型的疼痛。
IEEE Trans Biomed Eng. 2015 Jun;62(6):1604-13. doi: 10.1109/TBME.2015.2399374. Epub 2015 Feb 4.
6
Efficacy of the latest new stimulation patterns of spinal cord stimulation for intractable neuropathic pain compared to conventional stimulation: study protocol for a clinical trial.最新脊髓刺激新刺激模式治疗难治性神经性疼痛的疗效与传统刺激相比：临床试验研究方案。
Trials. 2023 Sep 23;24(1):604. doi: 10.1186/s13063-023-07637-x.
7
Pulse Intensity Effects of Burst and Tonic Spinal Cord Stimulation on Neural Responses to Brushing in Patients With Neuropathic Pain.爆发性和强直性脊髓刺激对神经性疼痛患者刷擦刺激神经反应的脉冲强度影响
Neuromodulation. 2023 Jul;26(5):975-987. doi: 10.1016/j.neurom.2022.11.001. Epub 2022 Dec 1.
8
Comparison of burst and tonic spinal cord stimulation on spinal neural processing in an animal model.动物模型中爆发性和强直性脊髓刺激对脊髓神经处理的比较。
Neuromodulation. 2014 Feb;17(2):143-51. doi: 10.1111/ner.12117. Epub 2013 Sep 24.
9
Burst and Tonic Spinal Cord Stimulation Both Activate Spinal GABAergic Mechanisms to Attenuate Pain in a Rat Model of Chronic Neuropathic Pain.爆发式和强直性脊髓刺激均可激活脊髓 GABA 能机制，从而减轻慢性神经病理性疼痛大鼠模型的疼痛。
Pain Pract. 2020 Jan;20(1):75-87. doi: 10.1111/papr.12831. Epub 2019 Sep 9.
10
Effect of spinal cord stimulation in an animal model of neuropathic pain relates to degree of tactile "allodynia".脊髓刺激在神经性疼痛动物模型中的作用与触觉“痛觉过敏”程度相关。
Neuroscience. 2006 Dec 1;143(2):541-6. doi: 10.1016/j.neuroscience.2006.08.007. Epub 2006 Sep 15.

本文引用的文献

1
The Challenge of Converting "Failed Spinal Cord Stimulation Syndrome" Back to Clinical Success, Using SCS Reprogramming as Salvage Therapy, through Neurostimulation Adapters Combined with 3D-Computerized Pain Mapping Assessment: A Real Life Retrospective Study.通过神经刺激适配器结合三维计算机化疼痛图谱评估，将脊髓刺激失败综合征转化为临床成功的挑战：以脊髓刺激重新编程作为挽救疗法的一项真实病例回顾性研究
J Clin Med. 2022 Jan 5;11(1):272. doi: 10.3390/jcm11010272.
2
Time-dynamic pulse modulation of spinal cord stimulation reduces mechanical hypersensitivity and spontaneous pain in rats.脊髓刺激的时动态脉冲调制可减少大鼠的机械性痛觉过敏和自发性疼痛。
Sci Rep. 2020 Nov 23;10(1):20358. doi: 10.1038/s41598-020-77212-w.
3
Spinal cord stimulation in chronic neuropathic pain: mechanisms of action, new locations, new paradigms.
慢性神经性疼痛中的脊髓刺激：作用机制、新部位、新范式。
Pain. 2020 Sep;161 Suppl 1(1):S104-S113. doi: 10.1097/j.pain.0000000000001854.
4
A Review of Clinical Data on Salvage Therapy in Spinal Cord Stimulation.脊髓刺激挽救治疗的临床数据回顾
Neuromodulation. 2020 Jul;23(5):562-571. doi: 10.1111/ner.13067. Epub 2019 Nov 7.
5
Spinal cord stimulation in chronic pain: evidence and theory for mechanisms of action.慢性疼痛中的脊髓刺激：作用机制的证据与理论
Bioelectron Med. 2019 Jun 28;5. doi: 10.1186/s42234-019-0023-1.
6
The Evolution of Neuromodulation in the Treatment of Chronic Pain: Forward-Looking Perspectives.神经调节治疗慢性疼痛的演变：前瞻性观点。
Pain Med. 2019 Jun 1;20(Suppl 1):S58-S68. doi: 10.1093/pm/pnz074.
7
NMDA Receptor Dependent Long-term Potentiation in Chronic Pain.NMDA 受体依赖性慢性痛觉过敏中的长时程增强。
Neurochem Res. 2019 Mar;44(3):531-538. doi: 10.1007/s11064-018-2614-8. Epub 2018 Aug 14.
8
Sub-paresthesia spinal cord stimulation reverses thermal hyperalgesia and modulates low frequency EEG in a rat model of neuropathic pain.脊髓亚麻痹性脊髓刺激逆转神经病理性疼痛大鼠模型的热痛觉过敏，并调节低频 EEG。
Sci Rep. 2018 May 8;8(1):7181. doi: 10.1038/s41598-018-25420-w.
9
Therapy-Related Explants After Spinal Cord Stimulation: Results of an International Retrospective Chart Review Study.脊髓刺激术后与治疗相关的取出装置：一项国际回顾性图表审查研究的结果
Neuromodulation. 2017 Oct;20(7):642-649. doi: 10.1111/ner.12642. Epub 2017 Aug 18.
10
Tonic and burst spinal cord stimulation waveforms for the treatment of chronic, intractable pain: study protocol for a randomized controlled trial.用于治疗慢性顽固性疼痛的强直性和爆发性脊髓刺激波形：一项随机对照试验的研究方案
Trials. 2016 Dec 1;17(1):569. doi: 10.1186/s13063-016-1706-5.