喉癌手术及临床治疗方式的成本-后果分析
Cost-consequence analysis of surgical and clinical treatment modalities of laryngeal cancer.
作者信息
Dos Santos Alexandre Bezerra, de Soárez Patrícia Coelho, Lopez Rossana Veronica Mendoza, Rozman Luciana Martins, Campolina Alessandro Gonçalves
机构信息
Departamento de Cirurgia de Cabeça e Pescoço, Instituto do Câncer do Estado de São Paulo, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
Departamento de Medicina Preventiva, Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, Brazil.
出版信息
Clinics (Sao Paulo). 2025 Apr 23;80:100585. doi: 10.1016/j.clinsp.2025.100585. eCollection 2025.
BACKGROUND
Laryngeal Squamous Cell Carcinoma (LSCC) may be treated clinically or surgically as a therapeutic option with a curative intention. The aim of this study is to compare direct medical costs and overall survival associated with the treatment of LSCC.
METHODS
Retrospective cost-consequence analysis, from the perspective of a Brazilian public hospital that included patients with LSCC, from 2014 to 2017. Unit costs were estimated using a macro-costing approach. The Propensity Score Matching method was used. Survival analyses were performed using the Kaplan-Meier method.
RESULTS
The therapeutic modalities were similar in terms of total costs: USD 32,259.65 for the clinical group and USD 34,385.87 for the surgical group (p = 0.215). Patients in the surgical group showed better overall survival than the clinical group (HR 0.53; p = 0.047).
CONCLUSION
Both therapeutic modalities for the treatment of LSCC showed similar total costs. Nevertheless, overall survival was better in the surgical group.
背景
喉鳞状细胞癌（LSCC）在临床上或手术上都可作为一种有治愈意图的治疗选择。本研究的目的是比较LSCC治疗的直接医疗成本和总生存期。
方法
从一家巴西公立医院的角度进行回顾性成本-效果分析，纳入2014年至2017年的LSCC患者。采用宏观成本核算方法估算单位成本。使用倾向得分匹配法。采用Kaplan-Meier法进行生存分析。
结果
治疗方式在总成本方面相似：临床组为32,259.65美元，手术组为34,385.87美元（p = 0.215）。手术组患者的总生存期优于临床组（HR 0.53；p = 0.047）。
结论
LSCC的两种治疗方式显示出相似的总成本。然而，手术组的总生存期更好。
Zotero 插件