探索铁死亡、凋亡和自噬之间细胞死亡相互作用与交叉的十字路口。
Navigating the crossroads of cell death interplay and intersections among ferroptosis, apoptosis and autophagy.
作者信息
Suchiita Anuupama, Gupta Navya, Nandi Kajal, Goswami Binita
机构信息
28862 Maulana Azad Medical College , New Delhi, India.
出版信息
Drug Metab Pers Ther. 2025 Apr 28. doi: 10.1515/dmpt-2024-0073.
The review article, "Navigating the Crossroads of Cell Death: Interplay and Intersections Among Ferroptosis, Apoptosis, and Autophagy," delves into the complex interactions between these three key cell death pathways. Understanding how ferroptosis, apoptosis, and autophagy intersect is crucial for maintaining cellular homeostasis. Each pathway represents a unique mechanism of cell death, and recent research highlights their intricate interconnections and mutual influences. Exploring these relationships is vital for comprehending how cells make fate decisions and how these processes are implicated in various diseases. The review's significance lies in elucidating the molecular details of cell death and providing insight into how cells balance survival and death. The interplay among ferroptosis, apoptosis, and autophagy has important implications for developing therapeutic interventions, particularly in diseases where cell death regulation is disrupted. By examining the molecular crosstalk between these pathways, researchers can identify new drug targets and devise strategies to modulate cell fate effectively. This review aims to enhance our understanding of cell biology by offering a detailed perspective on the dynamic and interconnected nature of these cell death mechanisms.
综述文章《探索细胞死亡的十字路口:铁死亡、凋亡与自噬之间的相互作用与交汇》深入探讨了这三种关键细胞死亡途径之间的复杂相互作用。了解铁死亡、凋亡与自噬如何交汇对于维持细胞内稳态至关重要。每种途径代表一种独特的细胞死亡机制,近期研究凸显了它们错综复杂的相互联系和相互影响。探索这些关系对于理解细胞如何做出命运决定以及这些过程如何牵涉到各种疾病至关重要。该综述的意义在于阐明细胞死亡的分子细节,并深入了解细胞如何平衡生存与死亡。铁死亡、凋亡与自噬之间的相互作用对于开发治疗干预措施具有重要意义,尤其是在细胞死亡调控被破坏的疾病中。通过研究这些途径之间的分子串扰,研究人员可以确定新的药物靶点,并设计有效调节细胞命运的策略。本综述旨在通过详细阐述这些细胞死亡机制的动态和相互联系的本质,增进我们对细胞生物学的理解。