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涎腺腺样囊性癌的最新见解:相关基因与分子途径

Current Insights on Salivary Gland Adenoid Cystic Carcinoma: Related Genes and Molecular Pathways.

作者信息

Zisis Vasileios, Poulopoulos Konstantinos, Shinas Nikolaos, Charisi Christina, Poulopoulos Athanasios

机构信息

Department of Oral Medicine and Pathology, Dental School, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.

Department of Oral and Maxillofacial Radiology, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA 02215, USA.

出版信息

Genes (Basel). 2025 Mar 24;16(4):370. doi: 10.3390/genes16040370.

Abstract

: Salivary adenoid cystic carcinoma (ACC) is a rare but aggressive neoplasm that predominantly arises from the salivary glands, accounting for a significant proportion of salivary gland cancers. The aim of this literature review is to illustrate the current insights on ACC with regards to related genes and molecular pathways by analyzing original research articles from the period 2015-2025. : An electronic search of literature was performed between January and February 2025 to identify all articles investigating the current insights on salivary gland adenoid cystic carcinoma and its related genes and molecular pathways. The search was conducted using MEDLINE (National Library of Medicine)-PubMed with restrictions concerning the date of publication. In particular, we focused on the period 2015-2025 using the following keywords: Salivary gland adenoid cystic carcinoma AND genes AND molecular pathways. This was followed by a manual search, and references were used to identify relevant articles. : In total, 41 articles were identified through the keywords. After the implementation of the time frame 2015-2025, 31 articles remained. Subsequently, by reading the titles and abstracts and thereby excluding non-original research articles and articles written in a language other than English, 23 articles remained. : These studies identified 23 relevant genes or pathways whose analysis yielded the most recent data regarding their function. The classification of ACC is multifaceted, encompassing distinct histological subtypes that are crucial for determining prognosis and treatment approaches. Current oncological practices classify ACC based on these histological features alongside emerging genetic and molecular markers that promise to enhance our understanding of the disease's biology. Diagnostic strategies have evolved, leveraging techniques such as biopsy and molecular diagnostics, which have significantly improved the detection and characterization of ACC. Regarding treatment, the management of ACC remains a challenge due to its propensity for local invasion and metastasis, with surgery, radiation, and chemotherapy being the mainstays of therapy. The development of targeted therapies based on ACC's molecular profile will allow for a better prognosis and an enhanced quality of life of patients.

摘要

涎腺腺样囊性癌(ACC)是一种罕见但具有侵袭性的肿瘤,主要起源于涎腺,在涎腺癌中占相当大的比例。本综述的目的是通过分析2015年至2025年期间的原创研究文章,阐述目前关于ACC相关基因和分子途径的见解。:2025年1月至2月进行了文献电子检索,以确定所有研究涎腺腺样囊性癌及其相关基因和分子途径当前见解的文章。检索使用了MEDLINE(美国国立医学图书馆)-PubMed,并对出版日期进行了限制。具体而言,我们使用以下关键词聚焦于2015年至2025年期间:涎腺腺样囊性癌、基因、分子途径。随后进行了手动检索,并利用参考文献确定相关文章。:通过关键词共确定了41篇文章。在实施2015年至2025年的时间框架后,剩下31篇文章。随后,通过阅读标题和摘要,排除非原创研究文章和非英文撰写的文章,剩下23篇文章。:这些研究确定了23个相关基因或途径,对其分析产生了关于其功能的最新数据。ACC的分类是多方面的,包括不同的组织学亚型,这些亚型对于确定预后和治疗方法至关重要。当前的肿瘤学实践根据这些组织学特征以及有望增强我们对疾病生物学理解的新兴基因和分子标记对ACC进行分类。诊断策略已经发展,利用活检和分子诊断等技术,这些技术显著提高了ACC的检测和特征描述。在治疗方面,由于ACC易于局部侵袭和转移,其管理仍然是一个挑战,手术、放疗和化疗是主要的治疗手段。基于ACC分子特征的靶向治疗的发展将使患者有更好的预后和更高的生活质量。

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