Suppr超能文献

退行性二尖瓣反流手术修复患者中的肥胖悖论

The Obesity Paradox in Patients Undergoing Surgical Repair of Degenerative Mitral Regurgitation.

作者信息

Issa Hugo M N, Rahmouni Kenza, Nantsios Alex, Messika-Zeitoun David, Ruel Marc, Mesana Thierry, Chan Vincent

机构信息

Division of Cardiac Surgery, University of Ottawa Heart Institute Ottawa, Ottawa, ON K1Y 4W7, Canada.

Division of Cardiology, University of Ottawa Heart Institute Ottawa, Ottawa, ON K1Y 4W7, Canada.

出版信息

J Clin Med. 2025 Apr 19;14(8):2817. doi: 10.3390/jcm14082817.

Abstract

The obesity paradox describes the beneficial influence of an elevated body mass index on health outcomes. Currently, few studies have evaluated BMI and its impact on survival following surgical repair of degenerative mitral regurgitation (MR). Between 2004 and 2021, 1214 patients underwent surgical mitral valve repair at our institution for MR due to myxomatous degeneration. Patient age was 63.2 ± 12.3 years, 341 (28%) were female, and 678 (55%) were either overweight or obese (body mass index ≥ 25 kg/m) preoperatively. Concomitant coronary revascularization was performed in 152 (13%). Clinical and echocardiographic follow-up averaged 4.5 years and was complete for all patients. Perioperative mortality occurred in 4 (0.3%). Ten-year survival, freedom from recurrent MR ≥ 2+, and freedom from recurrent MR ≥ 3+ was 75.1 ± 2.3%, 85.8 ± 2.1%, and 96.6 ± 1.0%, respectively. A higher body mass index was associated with better survival (hazard ratio 0.99, 95% CI 0.98-0.99, = 0.02) after adjusting for age, sex, preoperative LV function, and preoperative LV size. A higher BMI was associated with better long-term survival independent of age, gender, LV function, and LV size. These data may provide nuanced risk prognostication in patients undergoing surgical mitral repair.

摘要

肥胖悖论描述了升高的体重指数对健康结果的有益影响。目前,很少有研究评估体重指数及其对退行性二尖瓣反流(MR)手术修复后生存率的影响。在2004年至2021年期间,我们机构有1214例因黏液瘤样变性导致的MR患者接受了二尖瓣手术修复。患者年龄为63.2±12.3岁,341例(28%)为女性,678例(55%)术前超重或肥胖(体重指数≥25kg/m²)。152例(13%)患者同时进行了冠状动脉血运重建。临床和超声心动图随访平均4.5年,所有患者均完成随访。围手术期死亡率为4例(0.3%)。10年生存率、无≥2+级复发性MR率和无≥3+级复发性MR率分别为75.1±2.3%、85.8±2.1%和96.6±1.0%。在调整年龄、性别、术前左心室功能和术前左心室大小后,较高的体重指数与更好的生存率相关(风险比0.99,95%置信区间0.98 - 0.99,P = 0.02)。较高的体重指数与更好的长期生存率相关,且独立于年龄、性别、左心室功能和左心室大小。这些数据可能为接受二尖瓣手术修复的患者提供细致入微的风险预后评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/acb4/12028279/99bc3e34ca2b/jcm-14-02817-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验