Hage Adam, Janes Mikhaila, Best Sonja M
Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Division of Intramural Research, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.
Viruses. 2025 Apr 14;17(4):562. doi: 10.3390/v17040562.
Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity. This ubiquitous participation in fundamental aspects of biology has made TRIM proteins a focus of study in many fields and has illuminated the negative impact they exert when functioning improperly. Disruption of TRIM function has been linked to the success of various pathogens and separately to the occurrence and development of several neurodegenerative diseases, making TRIM proteins an appealing candidate to study for novel therapeutic approaches. Here, we review the current findings on TRIM proteins that demonstrate their analogous properties in the distinct fields of viral infection and central nervous system (CNS) disorders. We also examine recent advancements in drug development and targeted protein degradation as potential strategies for TRIM-mediated therapeutic treatments and discuss the implications these technologies have on future research directions.
三聚体基序（TRIM）蛋白是一类重要的E3泛素连接酶，可调节多种生物学过程，包括蛋白质表达、细胞信号通路和先天免疫。TRIM蛋白在生物学基本方面的广泛参与使其成为许多领域的研究焦点，并揭示了其功能异常时所产生的负面影响。TRIM功能的破坏与各种病原体的成功感染以及几种神经退行性疾病的发生和发展有关，这使得TRIM蛋白成为研究新型治疗方法的有吸引力的候选对象。在这里，我们回顾了关于TRIM蛋白的当前研究结果，这些结果证明了它们在病毒感染和中枢神经系统（CNS）疾病这两个不同领域中的类似特性。我们还研究了药物开发和靶向蛋白质降解方面的最新进展，将其作为TRIM介导的治疗性治疗的潜在策略，并讨论了这些技术对未来研究方向的影响。
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