Ahmad Fazil
Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, Jubail, Saudi Arabia.
Drug Dev Res. 2025 May;86(3):e70093. doi: 10.1002/ddr.70093.
Recent advances in pharmacology are revolutionizing drug discovery and treatment strategies through personalized medicine, pharmacogenomics, and artificial intelligence (AI). The objective of the present study is to review the role of personalized medicine, pharmacogenomics, and AI-based strategies in optimizing patient outcomes with improved drug efficacy and reduced side effects. A comprehensive review was performed to debate the utility of pharmacogenomics in the prediction of drug response, the role of AI in drug discovery, and the utility of personalized medicine in the clinic. This review highlights how drug discovery and treatment techniques are evolving with the aid of personalized medicine, pharmacogenomics, and AI. Personalized medicine makes the treatment fit the DNA pattern for higher efficacy and minimal side effects. Pharmacogenomics forecasts the action of a drug in terms of genetic difference. AI speeds up drug discovery to enhance the effectiveness and accuracy of finding and evaluating drug leads. Studies show that customized medicine charts therapy to an individual patient's individual genetic profile, resulting in better therapy. Pharmacogenomics facilitates precise drug selection by considering genetic variations, reducing adverse reactions. AI speeds up drug discovery by applying predictive modeling and data-driven evaluation to propel optimized drug development pathways. Together, these advances are enabling more efficient and safer treatment practices across medical disciplines. The combination of pharmacology, genomics, and AI is revolutionizing contemporary healthcare through the personalization of treatments, improved drug safety, and therapeutic outcomes. The future of research should be on optimizing these techniques and overcoming ethical and regulatory issues to facilitate broader clinical implementation.
药理学的最新进展正在通过精准医学、药物基因组学和人工智能(AI)彻底改变药物研发和治疗策略。本研究的目的是回顾精准医学、药物基因组学和基于人工智能的策略在优化患者治疗效果方面的作用,以提高药物疗效并减少副作用。我们进行了一项全面综述,以探讨药物基因组学在预测药物反应中的作用、人工智能在药物研发中的作用以及精准医学在临床中的应用。这篇综述强调了药物研发和治疗技术如何借助精准医学、药物基因组学和人工智能不断发展。精准医学使治疗方案符合DNA模式,以实现更高的疗效和最小的副作用。药物基因组学根据基因差异预测药物的作用。人工智能加速药物研发,以提高寻找和评估药物先导物的有效性和准确性。研究表明,定制化医学根据个体患者的基因特征制定治疗方案,从而实现更好的治疗效果。药物基因组学通过考虑基因变异促进精准的药物选择,减少不良反应。人工智能通过应用预测模型和数据驱动的评估来加速药物研发,推动优化的药物开发路径。总之,这些进展正在使各医学学科的治疗实践更加高效和安全。药理学、基因组学和人工智能的结合正在通过治疗的个性化、提高药物安全性和治疗效果,彻底改变当代医疗保健。未来的研究应致力于优化这些技术,克服伦理和监管问题,以促进更广泛的临床应用。