Rady Elias D, Anouti Ahmad, Thimphitthaya Chanattha, Cotter Thomas G
Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Clin Liver Dis. 2025 May;29(2):165-184. doi: 10.1016/j.cld.2024.12.001. Epub 2025 Jan 30.
Alcohol-associated liver disease (ALD) is the foremost cause of liver-related mortality in the United States comprising a spectrum of conditions from simple hepatic steatosis to more severe alcohol-associated cirrhosis and alcohol-associated hepatitis. There has been growing acceptance and application of early liver transplantation (eLT) for ALD. There is robust evidence for excellent patient and graft survival rates for eLT for ALD. Nevertheless, recidivism remains a major concern. This article aims to explore the recent trends in liver transplantation for ALD, as well as the advances in practice and outcomes, with focus on eLT and emerging challenges in this field.
酒精性肝病（ALD）是美国肝脏相关死亡的首要原因，涵盖了从单纯性肝脂肪变性到更严重的酒精性肝硬化和酒精性肝炎等一系列病症。早期肝移植（eLT）在ALD中的应用越来越受到认可。有充分证据表明，ALD患者接受eLT后，患者和移植物的存活率都很高。然而，复发性疾病仍然是一个主要问题。本文旨在探讨ALD肝移植的最新趋势，以及实践和治疗结果方面的进展，重点关注eLT及其在该领域面临的新挑战。
