肝移植在原发性和继发性肝脏恶性肿瘤中的作用。

Role of Liver Transplant in Primary and Secondary Liver Malignancies.

作者信息

Melehy Andrew, Agopian Vatche G

机构信息

Department of Surgery, Dumont-UCLA Transplant and Liver Cancer Centers, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.

Division of Liver and Pancreas Transplantation, Department of Surgery, Dumont-UCLA Transplant and Liver Cancer Centers, David Geffen School of Medicine at University of California, Los Angeles, CA, USA.

出版信息

Clin Liver Dis. 2025 May;29(2):217-234. doi: 10.1016/j.cld.2024.12.003. Epub 2025 Feb 24.

DOI:10.1016/j.cld.2024.12.003

PMID:40287268

Abstract

Hepatocellular carcinoma (HCC) and cholangiocarcinoma are the primary hepatic malignancies with established pathways to transplantation and model for end-stage liver disease (MELD) exception points. Other tumors managed with liver transplantation (LT) include hepatic epithelioid hemangioendothelioma and fibrolamellar HCC. LT for metastatic neuroendocrine tumor has been established with patient selection criteria and a path to MELD exception points. Additionally, recent data on LT for patients with unresectable hepatic colorectal metastases demonstrate increasingly encouraging initial results.

摘要

肝细胞癌（HCC）和胆管癌是主要的肝脏恶性肿瘤，有既定的移植途径和终末期肝病模型（MELD）例外点。其他通过肝移植（LT）治疗的肿瘤包括肝上皮样血管内皮瘤和纤维板层型HCC。转移性神经内分泌肿瘤的肝移植已确立了患者选择标准和获得MELD例外点的途径。此外，最近关于不可切除的肝结直肠癌转移患者肝移植的数据显示出越来越令人鼓舞的初步结果。