Paton Hanna, Sarkar Prabuddha, Gurung Prajwal
Inflammation Program, University of Iowa, 431 Newton Road, Iowa City, IA 52242, United States.
Department of Internal Medicine, University of Iowa, 431 Newton Road, Iowa City, IA 52442, United States.
Hum Mol Genet. 2025 Oct 7;34(R1):R83-R109. doi: 10.1093/hmg/ddaf043.
Leishmania spp. infections pose a significant global health challenge, affecting approximately 1 billion people across more than 88 endemic countries. This unicellular, obligate intracellular parasite causes a spectrum of diseases, ranging from localized cutaneous lesions to systemic visceral infections. Despite advancements in modern medicine and increased understanding of the parasite's etiology and associated diseases, treatment options remain limited to pentavalent antimonials, liposomal amphotericin B, and miltefosine. A deeper understanding of the interactions between immune and non-immune cells involved in the clearance of Leishmania spp. infections could uncover novel therapeutic strategies for this debilitating disease. This review highlights recent progress in elucidating how various cell types contribute to the regulation and resolution of Leishmania spp. infections.
利什曼原虫属感染对全球健康构成重大挑战，影响着88个以上流行国家的约10亿人。这种单细胞专性细胞内寄生虫会引发一系列疾病，从局部皮肤损伤到全身性内脏感染。尽管现代医学取得了进展，人们对该寄生虫的病因及相关疾病的了解也有所增加，但治疗选择仍局限于五价锑剂、脂质体两性霉素B和米替福新。更深入地了解参与清除利什曼原虫属感染的免疫细胞和非免疫细胞之间的相互作用，可能会为这种使人衰弱的疾病发现新的治疗策略。本综述重点介绍了在阐明各种细胞类型如何促进利什曼原虫属感染的调节和消退方面的最新进展。
