Gulati Kankan, Gunasekaran Durai Murukan, Bhargav Hemant, Bhaskarapillai Binukumar, Nandakumar D N, Varambally Shivarama, Gangadhar B N, Desai Geetha
Department of Integrative Medicine, NIMHANS, Bengaluru, Karnataka, India.
Department of Biostatistics, NIMHANS, Bengaluru, Karnataka, India.
Indian J Psychiatry. 2025 Mar;67(3):316-322. doi: 10.4103/indianjpsychiatry.indianjpsychiatry_932_24. Epub 2025 Mar 14.
Patients diagnosed with somatoform pain disorders (SPDs) experience chronic pain without any obvious etiology and repeatedly seek medical help to find some relief from the symptoms.
In this study, the effect of 24 weeks of add-on yoga therapy was assessed on pain in patients diagnosed with SPDs through an open-label trial.
Seventy subjects (42 women) with a group mean age ± standard deviation (SD) of 35.41 ± 6.55 years, depending on their preference, were assigned to two groups, Yoga Group (YG: Yoga + standard treatment) (n = 38) or Wait-list Control Group (CG: standard treatment alone) (n = 32). An open-label, assessor-blind, controlled trial design was followed. The primary outcome variable was the severity of pain measured on a Visual Analog Scale (VAS). Secondary outcome variables included anxiety [Hamilton Anxiety Rating Scale (HAM-A)], depression [Hamilton Depression Rating Scale (HAM-D)], somatic symptoms [Scale for Assessment of Somatic Symptoms (SASS)], disability (WHODAS 2.0), and quality of life (WHOQOL-BREF). Assessment time points were baseline and 12 weeks for all the variables except pain, which was assessed at points 0, 2 weeks, 6 weeks, 12 weeks, and 24 weeks. Data were analyzed using Friedman's test (LOCF method filled out missing values) and linear mixed model analysis.
Post intervention, there was a significant improvement in the pain scores of patients in the YG compared to the CG at 24 weeks ( < 0.001). Significant between-group improvements favoring the YG group were also observed in the scores of anxiety ( < 0.01), depression ( < 0.05), somatic symptoms ( < 0.01), and physical health-related quality of life ( < 0.01) at 12 weeks. We also observed that patients in the YG group adhered to the treatment better at the end of 24 weeks than the CG group.
Adding yoga therapy to standard treatment improved scores of pain, anxiety, depression, somatic symptoms, and physical health-related quality of life in SPDs compared to standard treatment alone.
被诊断为躯体形式疼痛障碍（SPD）的患者经历慢性疼痛，却无任何明显病因，并反复寻求医疗帮助以缓解症状。
在本研究中，通过一项开放标签试验评估了为期24周的附加瑜伽疗法对被诊断为SPD患者疼痛的影响。
70名受试者（42名女性），组平均年龄±标准差（SD）为35.41±6.55岁，根据他们的偏好分为两组，瑜伽组（YG：瑜伽+标准治疗）（n = 38）或等待列表对照组（CG：仅标准治疗）（n = 32）。采用开放标签、评估者盲法、对照试验设计。主要结局变量是用视觉模拟量表（VAS）测量的疼痛严重程度。次要结局变量包括焦虑[汉密尔顿焦虑评定量表（HAM - A）]、抑郁[汉密尔顿抑郁评定量表（HAM - D）]、躯体症状[躯体症状评估量表（SASS）]、残疾（WHODAS 2.0）和生活质量（WHOQOL - BREF）。除疼痛在0、2周、6周、12周和24周进行评估外，所有变量的评估时间点为基线和12周。数据采用弗里德曼检验（用末次观察结转法填补缺失值）和线性混合模型分析。
干预后，与CG组相比，YG组患者在24周时疼痛评分有显著改善（<0.001）。在12周时，在焦虑（<0.01）、抑郁（<0.05）、躯体症状（<0.01）和与身体健康相关的生活质量（<0.01）评分方面也观察到有利于YG组的显著组间改善。我们还观察到，在24周结束时，YG组患者比CG组患者对治疗的依从性更好。
与仅标准治疗相比，在标准治疗中添加瑜伽疗法可改善SPD患者的疼痛、焦虑、抑郁、躯体症状和与身体健康相关的生活质量评分。
