肺典型类癌的性别差异、预后指标及生存差异：一项监测、流行病学和最终结果（SEER）数据库分析

Gender disparities, prognostic indicators, and survival differences in pulmonary typical carcinoid: a SEER database analysis.

作者信息

Ahmed Asim, Yasinzai Abdul Qahar Khan, Tareen Bisma, Wali Agha, Khan Marjan, Tijani Lukman, Ullah Asad

机构信息

Medical College of Georgia, Augusta, Georgia, USA.

University of Florida Health Cancer Center, Gainesville, Florida, USA.

出版信息

Proc (Bayl Univ Med Cent). 2025 Feb 24;38(3):241-245. doi: 10.1080/08998280.2025.2464454. eCollection 2025.

DOI:10.1080/08998280.2025.2464454

PMID:40291097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12026113/

Abstract

BACKGROUND

Typical carcinoid is a subtype of neuroendocrine neoplasia of the lung making up <1% of all lung cancers and 2% of resected lung tumors. This study assessed the impact of demographic features, racial and gender disparities, and tumor characteristics on survival in patients with typical carcinoid tumors.

METHODS

Data were extracted from the SEER database from 2000 to 2018. Multivariate Cox regression analyses were used to analyze the survival based on demographic and clinical factors.

RESULTS

We identified 11,713 cases of typical carcinoid tumors of the lungs. The mean age was 61.8 years (standard deviation, 14.7), and the tumors affected predominantly women (70.1%) and White (89.4%) individuals. The overall 5-year survival rate was 84.3% (95% confidence interval [CI] 83.5-85.2). The 5-year survival rate for those treated with systemic therapy was 49.8% (95% CI 43.5-55.9). Those treated with surgery had a 5-year survival rate of 97.2% (95% CI 96.7-97.6), and those treated with radiation had a 5-year survival rate of 71.9% (95% CI 60.3-80.6). Combination therapy provided a survival rate of 86.9% (95% CI 64.6-95.6).

CONCLUSION

Surgery was the most common treatment modality and offered the best prognosis. On multivariate analysis, age >60, male gender, distant spread, and liver metastases were associated with worse prognosis.

摘要

背景

典型类癌是肺神经内分泌肿瘤的一种亚型，占所有肺癌的比例不到1%，在切除的肺肿瘤中占2%。本研究评估了人口统计学特征、种族和性别差异以及肿瘤特征对典型类癌患者生存的影响。

方法

数据来自2000年至2018年的监测、流行病学和最终结果（SEER）数据库。采用多变量Cox回归分析来分析基于人口统计学和临床因素的生存率。

结果

我们识别出11713例肺典型类癌病例。平均年龄为61.8岁（标准差为14.7），肿瘤主要影响女性（70.1%）和白人（89.4%）个体。总体5年生存率为84.3%（95%置信区间[CI]83.5 - 85.2）。接受全身治疗的患者5年生存率为[49.8%（95%CI 43.5 - 55.9）。接受手术治疗的患者5年生存率为97.2%（95%CI 96.7 - 97.6），接受放疗的患者5年生存率为71.9%（95%CI 60.3 - 80.6）。联合治疗的生存率为86.9%（95%CI 64.6 - 95.6）。