Jha Shailesh, Jena Amarnath, Rana Prerana, Bhagat Achal
Department of Psychiatry, Indraprastha Apollo Hospitals and Saarthak Mental Health Services, Delhi, India.
Department of Molecular Imaging and Nuclear Medicine, PET Suite (Indraprastha Apollo Hospitals and House of Diagnostics), Delhi, India.
Indian J Nucl Med. 2024 Nov-Dec;39(6):449-453. doi: 10.4103/ijnm.ijnm_112_24. Epub 2025 Mar 20.
Obsessive-compulsive disorder is among the most extensively researched mental health disorder. Various metabolic neuroimaging research findings are consistent but still nonconclusive. The major limitation is a homogeneous sample. There are research findings which have established the impact of treatment in changing brain metabolism. Therefore, it is important to highlight differential metabolic changes with respect to treatment staging and its outcome. It will also help to individualized neuromodulation protocol based on differential metabolic findings. This study highlights the distinct differential fluorodeoxyglucose metabolic changes among two distinct cases: drug-naïve and treatment-refractory.
强迫症是研究最为广泛的心理健康障碍之一。各种代谢神经影像学研究结果一致，但仍无定论。主要局限性在于样本缺乏异质性。有研究结果已证实治疗对改变脑代谢的影响。因此，突出治疗分期及其结果方面的代谢差异变化很重要。这也将有助于根据代谢差异结果制定个性化的神经调节方案。本研究突出了两个不同病例（未用药和治疗难治性）之间明显的氟脱氧葡萄糖代谢差异变化。
