Li Xinyang, Li Changfei, Liu Tiemei
Department of Blood Transfusion, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Patient Service Center, The Second Hospital of Jilin University, Changchun, Jilin, China.
Front Physiol. 2025 Apr 11;16:1445757. doi: 10.3389/fphys.2025.1445757. eCollection 2025.
Fetomaternal haemorrhage is the same immunity that occurs when foetal and maternal blood are incompatible. It is critical to accurately quantify maternal haemorrhaging in order to prevent hemolytic disease in the infant. At this time, the rosette test and K-B test are the most frequently used techniques for detecting foetal red blood cells in the mother's blood. However, the sensitivity of the rosette test is low, and due to its complex operation and high subjectivity, the K-B test cannot be used as a routine clinical detection method. This review therefore focuses primarily on the clinical landscape and future prospects of methods for detecting fetomaternal haemorrhage. In a general sense, this may bring to light the most promising strategy and encourage the development of technology for fetomaternal haemorrhage in order to guarantee the early detection and prevention of hemolytic disease in newborns.
胎儿-母体出血是指胎儿和母体血液不相容时发生的同种免疫反应。准确量化母体出血对于预防婴儿溶血病至关重要。目前，玫瑰花结试验和K-B试验是检测母体血液中胎儿红细胞最常用的技术。然而，玫瑰花结试验的灵敏度较低，且K-B试验操作复杂、主观性强，不能作为常规临床检测方法。因此，本综述主要关注检测胎儿-母体出血方法的临床现状和未来前景。一般来说，这可能会揭示最有前景的策略，并推动胎儿-母体出血检测技术的发展，以确保早期发现和预防新生儿溶血病。
