Shao Chenwei, Chen Hao, Liu Tingting, Pan Chun
Institute of Translational Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Department of Orthopedics, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China.
PeerJ. 2025 Apr 22;13:e19334. doi: 10.7717/peerj.19334. eCollection 2025.
Bone is the main structure of the human body; it mainly plays a supporting role and participates in metabolic processes. The Hippo signaling pathway is composed of a series of protein kinases, including the mammalian STE20-like kinase MST1/2 and the large tumor suppressor LATS1/2, which are widely involved in pathophysiological processes, including cell proliferation, differentiation, apoptosis and death, especially those related to biomechanical transduction . However, the role of it in regulating skeletal system development and the evolution of bone-related diseases remains poorly understood. The pathway can intervene in and regulate the physiological activities of bone-related cells such as osteoclasts and chondrocytes through its own or other bone-related signaling pathways, such as the Wnt pathway, the Notch pathway, and receptor activator of nuclear factor-κB ligand (RANKL), thereby affecting the occurrence and development of bone diseases. This article discusses the role of the Hippo signaling pathway in bone development and disease to provide new insights into the treatment of bone-related diseases by targeting the Hippo signaling pathway.
骨骼是人体的主要结构；它主要起支撑作用并参与代谢过程。Hippo信号通路由一系列蛋白激酶组成，包括哺乳动物STE20样激酶MST1/2和大肿瘤抑制因子LATS1/2，其广泛参与病理生理过程，包括细胞增殖、分化、凋亡和死亡，尤其是那些与生物力学转导相关的过程。然而，其在调节骨骼系统发育及骨相关疾病演变中的作用仍知之甚少。该信号通路可通过自身或其他骨相关信号通路（如Wnt通路、Notch通路和核因子κB受体活化因子配体（RANKL））干预和调节破骨细胞、软骨细胞等骨相关细胞的生理活动，从而影响骨疾病的发生发展。本文探讨Hippo信号通路在骨骼发育和疾病中的作用，旨在为通过靶向Hippo信号通路治疗骨相关疾病提供新的见解。
