文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

阿霉素和负载NFL-TBS.40-63肽的金纳米颗粒作为胶质母细胞瘤的多模态治疗方法。

Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma.

作者信息

Moutaoukil Myriam El, Lolli Maria Grazia, D'Amone Stefania, Khan Memona, Grillo Roberta, Eyer Joel, Grieco Maddalena, Ursini Ornella, Spadavecchia Jolanda, Cortese Barbara

机构信息

CNRS, NBD-CSPBAT, Laboratory of Chemistry, Structures and Properties of Biomaterials and Therapeutic Agents University Paris13, Sorbonne Paris Nord, Bobigny, France.

National Research Council - Institute of Nanotechnology (CNR Nanotec), c/o Department of Physics "E. Fermi", University Sapienza, Pz.le Aldo Moro 5, 00185, Rome, Italy.

出版信息

Discov Nano. 2025 Apr 28;20(1):72. doi: 10.1186/s11671-025-04249-z.

DOI:10.1186/s11671-025-04249-z
PMID:40293574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12037963/
Abstract

Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood-brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptide and the chemotherapeutic agent doxorubicin. This platform integrates targeted delivery and therapeutic action to enhance efficacy while minimising off-target effects. Our findings reveal superior cellular uptake, dose- and time-dependent cytotoxicity, and apoptosis induction in GBM cells compared to mono-functionalized counterparts. Furthermore, pH-sensitive drug release profiles underscore the system's potential to exploit the tumour microenvironment's acidic conditions for precise drug delivery. Comprehensive characterisation confirmed the stability, biocompatibility, and functional efficacy of the dual-functionalized AuNPs. This study highlights the promise of these nanoconjugates as a multimodal approach to GBM therapy, paving the way for further translational research in nanomedicine.

摘要

胶质母细胞瘤（GBM）的传统治疗方法受到全身毒性、血脑屏障穿透有限和治疗耐药性的阻碍。为应对这些挑战，我们开发了与生物素化的NFL-TBS.40-63肽和化疗药物阿霉素偶联的双功能化金纳米颗粒（AuNPs）。该平台整合了靶向递送和治疗作用，以提高疗效，同时将脱靶效应降至最低。我们的研究结果显示，与单功能化的对应物相比，GBM细胞对其细胞摄取更高、具有剂量和时间依赖性细胞毒性以及诱导细胞凋亡。此外，pH敏感的药物释放曲线突出了该系统利用肿瘤微环境酸性条件进行精确药物递送的潜力。全面表征证实了双功能化AuNPs的稳定性、生物相容性和功能功效。这项研究突出了这些纳米偶联物作为GBM治疗的多模态方法的前景，为纳米医学的进一步转化研究铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/e0f855f15521/11671_2025_4249_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/e5f184df9bb0/11671_2025_4249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/37ab886db886/11671_2025_4249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/db469642cdb3/11671_2025_4249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/f96f96bd8b1b/11671_2025_4249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/db784e3d9ae4/11671_2025_4249_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/e0f855f15521/11671_2025_4249_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/e5f184df9bb0/11671_2025_4249_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/37ab886db886/11671_2025_4249_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/db469642cdb3/11671_2025_4249_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/f96f96bd8b1b/11671_2025_4249_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/db784e3d9ae4/11671_2025_4249_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7414/12037963/e0f855f15521/11671_2025_4249_Fig6_HTML.jpg

相似文献

[1]
Doxorubicin and NFL-TBS.40-63 peptide loaded gold nanoparticles as a multimodal therapy of glioblastoma.

Discov Nano. 2025-4-28

[2]
Biological activity of gold nanoparticles combined with the NFL-TBS.40-63 peptide, or with other cell penetrating peptides, on rat glioblastoma cells.

Int J Pharm X. 2022-9-16

[3]
Targeted Chemo-Phototherapy in Red Light with Novel Doxorubicin and Iron(III) Complex-Functionalized Gold Nanoconjugate (Dox-Fe@FA-AuNPs).

Chem Asian J. 2024-9-16

[4]
Investigation on the self-assembly of the NFL-TBS.40-63 peptide and its interaction with gold nanoparticles as a delivery agent for glioblastoma.

Int J Pharm X. 2022-9-22

[5]
Doxorubicin-loaded iron oxide nanoparticles for glioblastoma therapy: a combinational approach for enhanced delivery of nanoparticles.

Sci Rep. 2020-7-9

[6]
The Application of Ultrasmall Gold Nanoparticles (2 nm) Functionalized with Doxorubicin in Three-Dimensional Normal and Glioblastoma Organoid Models of the Blood-Brain Barrier.

Molecules. 2024-5-24

[7]
Targeted Glioblastoma Treatment via Synthesis and Functionalization of Gold Nanoparticles With De Novo-Engineered Transferrin-Like Peptides: Protocol for a Novel Method.

JMIR Res Protoc. 2023-8-11

[8]
The use of liposomes functionalized with the NFL-TBS.40-63 peptide as a targeting agent to cross the in vitro blood-brain barrier and target glioblastoma cells.

Int J Pharm. 2023-11-5

[9]
Facile synthesis of lactoferrin conjugated ultra small large pore silica nanoparticles for the treatment of glioblastoma.

Nanoscale. 2021-10-21

[10]
Ligand-Mediated and Enzyme-Directed Precise Targeting and Retention for the Enhanced Treatment of Glioblastoma.

ACS Appl Mater Interfaces. 2017-6-7

本文引用的文献

[1]
Doxorubicin-Conjugated Nanoparticles for Potential Use as Drug Delivery Systems.

Nanomaterials (Basel). 2025-1-17

[2]
Biotin-functionalized nanoparticles: an overview of recent trends in cancer detection.

Nanoscale. 2024-7-11

[3]
A recent insight of applications of gold nanoparticles in glioblastoma multiforme therapy.

Int J Pharm. 2024-7-20

[4]
Spectroscopic Assessment of Doxorubicin (DOX)-Gemcitabine (GEM) Gold Complex Nanovector as Diagnostic Tool of Galectin-1 Biomarker.

Nanotechnol Sci Appl. 2024-3-29

[5]
The use of liposomes functionalized with the NFL-TBS.40-63 peptide as a targeting agent to cross the in vitro blood-brain barrier and target glioblastoma cells.

Int J Pharm. 2023-11-5

[6]
Nanomedicine in cancer therapy.

Signal Transduct Target Ther. 2023-8-7

[7]
Study of biological properties of gold nanoparticles: Low toxicity, no proliferative activity, no ability to induce cell gene expression and no antiviral activity.

Chem Biol Interact. 2023-9-1

[8]
Nanoparticles-induced potential toxicity on human health: Applications, toxicity mechanisms, and evaluation models.

MedComm (2020). 2023-7-14

[9]
NFL-TBS.40-63 Peptide Gold Complex Nanovector: A Novel Therapeutic Approach to Increase Anticancer Activity by Breakdown of Microtubules in Pancreatic Adenocarcinoma (PDAC).

ACS Pharmacol Transl Sci. 2022-10-14

[10]
Plate reader spectroscopy as an alternative to atomic absorption spectroscopy for the assessment of nanoparticle cellular uptake.

Heliyon. 2022-11-16

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索