L-谷氨酰胺和透明质酸联合光生物调节对口腔黏膜炎的影响：一项随机临床试验。

Effects of L-glutamine and hyaluronic acid associated with photobiomodulation on oral mucositis: a randomized clinical trial.

作者信息

Dos Santos Rodrigo Wilmes, Martins Allisson Filipe Lopes, Sousa-Neto Sebastião Silvério, Morais Marília Oliveira, de Oliveira Moreira Victor Hugo Lopes, Arantes Diego Antonio Costa, Oton-Leite Angélica Ferreira, Freitas Nilceana Maya Aires, Leles Cláudio Rodrigues, Mendonça Elismauro Francisco

机构信息

Universidade Federal de Goiás, Avenida Universitária Esquina Com 1ª Avenida, S/N. Setor Universitário, Goiânia, Goiás, CEP: 74605 - 220, Brazil.

Universidade Evangélica de Goiás, Dentistry School, Av. Universitária, S/N - Cidade Universitária, Anápolis, Goiás, CEP: 75083 - 515, Brazil.

出版信息

Support Care Cancer. 2025 Apr 28;33(5):430. doi: 10.1007/s00520-025-09480-z.

DOI:10.1007/s00520-025-09480-z

PMID:40295318

Abstract

OBJECTIVE

To investigate whether the application of L-glutamine (L-G) and hyaluronic acid (HA) associated with photobiomodulation (PBM) and the Preventive Oral Care Protocol (POCP) would present similar efficacy as the exclusive use of PBM, associated with POCP, in the prevention and control of severe oral mucositis (OM).

STUDY DESIGN

Patients with head and neck cancer undergoing radiochemotherapy (RCT) were randomized into two groups: group A, patients that received PBM + POCP (n = 24), and group B, patients that received PBM + POCP + L-G + HA (n = 24). OM was assessed using the National Cancer Institute (NCI) and World Health Organization (WHO) scales. The impact of oral health on patients' quality of life and perception of OM symptoms was evaluated. Assessments were made at the 1st, 7th, 14th, 21st, and 30th radiotherapy (RT) sessions.

RESULTS

When the severity of OM was assessed according to the WHO scale in the 30th RT, group B showed lower rates of severe OM than group A. There were no differences when using the NCI scale. The impact of oral health on quality of life and the symptoms reported by patients were lower in group B at all times evaluated.

CONCLUSION

The combination of PBM + POCP + L-G + HA resulted in a significantly lower severity of OM than PBM + POCP alone, according to the WHO scale at the 30th RT.

TRIAL REGISTRATION

Brazilian Clinical Trials Registry-REBEC no. RBR-6ybmgcv. Registration March 27, 2022.

摘要

目的

探讨L-谷氨酰胺（L-G）和透明质酸（HA）联合光生物调节（PBM）及预防性口腔护理方案（POCP）在预防和控制重度口腔黏膜炎（OM）方面是否与单独使用PBM联合POCP具有相似的疗效。

研究设计

将接受放化疗（RCT）的头颈癌患者随机分为两组：A组，接受PBM + POCP的患者（n = 24）；B组，接受PBM + POCP + L-G + HA的患者（n = 24）。使用美国国立癌症研究所（NCI）和世界卫生组织（WHO）的量表评估口腔黏膜炎。评估口腔健康对患者生活质量的影响以及对口腔黏膜炎症状的感知。在第1、7、14、21和30次放疗（RT）疗程时进行评估。