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多组学方法识别出与抑郁症相关的肠道微生物群变化。

Multi-omics approach identifies gut microbiota variations associated with depression.

作者信息

Hernández-Cacho Adrián, García-Gavilán Jesús F, Atzeni Alessandro, Konstanti Prokopis, Belzer Clara, Vioque Jesús, Corella Dolores, Fitó Montserrat, Vidal Josep, Mela Virginia, Liang Liming, Torres-Collado Laura, Coltell Oscar, Babio Nancy, Clish Clary, Hernando-Redondo Javier, Martínez-González Miguel Á, Wang Fenglei, Moreno-Indias Isabel, Ni Jiaqi, Dennis Courtney, Ruiz-Canela Miguel, Tinahones Francisco J, Hu Frank B, Salas-Salvadó Jordi

机构信息

Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain.

Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain.

出版信息

NPJ Biofilms Microbiomes. 2025 Apr 28;11(1):68. doi: 10.1038/s41522-025-00707-9.

DOI:10.1038/s41522-025-00707-9
PMID:40295565
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12038053/
Abstract

The gut microbiota plays a potential role in the pathophysiology of depression through the gut-brain axis. This cross-sectional study in 400 participants from the PREDIMED-Plus study investigates the interplay between gut microbiota and depression using a multi-omics approach. Depression was defined as antidepressant use or high Beck Depression Inventory-II scores. Gut microbiota was characterized by 16S rRNA sequencing, and faecal metabolites were analysed via liquid chromatography-tandem mass spectrometry. Participants with depression exhibited significant differences in gut microbial composition and metabolic profiles. Differentially abundant taxa included Acidaminococcus, Christensenellaceae R-7 group, and Megasphaera, among others. Metabolomic analysis revealed 15 significantly altered metabolites, primarily lipids, organic acids, and benzenoids, some of which correlated with gut microbial features. This study highlights the interplay between the gut microbiota and depression, paving the way for future research to determine whether gut microbiota influences depression pathophysiology or reflects changes associated with depression.

摘要

肠道微生物群通过肠-脑轴在抑郁症的病理生理学中发挥潜在作用。这项针对PREDIMED-Plus研究中400名参与者的横断面研究，采用多组学方法研究肠道微生物群与抑郁症之间的相互作用。抑郁症定义为使用抗抑郁药或贝克抑郁量表-II得分较高。通过16S rRNA测序对肠道微生物群进行表征，并通过液相色谱-串联质谱法分析粪便代谢物。患有抑郁症的参与者在肠道微生物组成和代谢谱方面表现出显著差异。差异丰富的分类群包括氨基酸球菌、克里斯滕森菌科R-7组和巨球形菌等。代谢组学分析揭示了15种显著改变的代谢物，主要是脂质、有机酸和苯类化合物，其中一些与肠道微生物特征相关。这项研究突出了肠道微生物群与抑郁症之间的相互作用，为未来研究确定肠道微生物群是否影响抑郁症病理生理学或反映与抑郁症相关的变化铺平了道路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/682e9dc1f105/41522_2025_707_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/9208f834a6bc/41522_2025_707_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/2c17ea017310/41522_2025_707_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/37c791fa9ce4/41522_2025_707_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/6b4a527acc51/41522_2025_707_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/41e2d71c4b56/41522_2025_707_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/682e9dc1f105/41522_2025_707_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/9208f834a6bc/41522_2025_707_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/2c17ea017310/41522_2025_707_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/37c791fa9ce4/41522_2025_707_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/6b4a527acc51/41522_2025_707_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/41e2d71c4b56/41522_2025_707_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ade/12038053/682e9dc1f105/41522_2025_707_Fig6_HTML.jpg

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引用本文的文献

[1]
The Gut Microbiota Is Altered in Antidepressant-Free Depressed Patients and Is Associated With Depression Severity.

J Neurochem. 2025-7

本文引用的文献

[1]
Effect of ultra-processed food consumption on the gut microbiota in the first year of life: Findings from the MINA-Brazil birth cohort study.

Clin Nutr. 2025-3

[2]
A Fully Remote Randomized Trial of Transcranial Alternating Current Stimulation for the Acute Treatment of Major Depressive Disorder.

J Clin Psychiatry. 2024-4-22

[3]
Characterization of the oral microbiota and the relationship of the oral microbiota with the dental and periodontal status in children and adolescents with nonsyndromic cleft lip and palate. Systematic literature review and meta-analysis.

Clin Oral Investig. 2024-4-8

[4]
Effects of chronic unpredictable mild stress on gut microbiota and fecal amino acid and short-chain fatty acid pathways in mice.

Behav Brain Res. 2024-4-27

[5]
Metabolomic signatures of inflammation and metabolic dysregulation in relation to colorectal cancer risk.

J Natl Cancer Inst. 2024-7-1

[6]
Metabolomic profiles of sleep-disordered breathing are associated with hypertension and diabetes mellitus development.

Nat Commun. 2024-2-28

[7]
Integrated multi-omics analysis reveals gut microbiota dysbiosis and systemic disturbance in major depressive disorder.

Psychiatry Res. 2024-4

[8]
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer.

Cell Rep Med. 2024-3-19

[9]
Sex-specific differences in intestinal microbiota associated with cardiovascular diseases.

Biol Sex Differ. 2024-1-19

[10]
The Role of IL-6 in Neurodegenerative Disorders.

Neurochem Res. 2024-4

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