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Very high prevalence of osteosarcopenia in hip fracture patients: risk and protective factors.

作者信息

Wong Ronald Man Yeung, Wong Pui Yan, Chau Wai Wang, Liu Chaoran, Zhang Ning, Cheung Wing Hoi

机构信息

Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China.

出版信息

J Orthop Surg Res. 2025 Apr 28;20(1):423. doi: 10.1186/s13018-025-05828-7.


DOI:10.1186/s13018-025-05828-7
PMID:40296076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12036194/
Abstract

BACKGROUND: Hip fractures are one of the most serious forms of osteoporotic fractures. Osteosarcopenia is a growing geriatric giant with increased risk of falls, fractures, disability and mortality. The objective of this cross-sectional study was to determine the prevalence and risk factors of osteosarcopenia amongst hip fracture patients. METHODS: All patients received a dual energy x-ray absorptiometry (DXA) scan for diagnosis of osteopenia and osteoporosis. For sarcopenia assessment, patients received a bioimpedance analysis (BIA) measurement, handgrip strength and 5-time chair stand test. Osteosarcopenia was defined with the presence of osteopenia/osteoporosis and sarcopenia. Risk factors for osteosarcopenia were analysed using logistic regression. RESULTS: A total of 342 hip fracture patients (n = 342) were recruited. Sarcopenia was present in 286 hip fracture patients (83.6%). 335 hip fracture patients (97.95%) had osteopenia/osteoporosis. Osteosarcopenia was present in 281 hip fracture patients (82.2%). For osteosarcopenia, patients with body mass index (BMI) < 23 kg/m were 4.33 (2.35 to 7.95; p < 0.001) times more likely to have osteosarcopenia regardless of age and gender. Males were 3.24 (1.38 to 7.58; p = 0.007) more likely to have osteosarcopenia regardless of age and BMI group. CONCLUSIONS: Our study had shown a very high prevalence of osteosarcopenia amongst hip fracture patients, especially in male patients, and identified associated risk and protective factors. Given the potential clinical implications, we would recommend that in addition to bone mineral density assessment, routine sarcopenia assessment should also be incorporated into Fracture Liaison Services. Further research should be conducted on optimal body weight and BMI, and as to why male patients have more likelihood of sarcopenia.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50a/12036194/fa51d29cd11f/13018_2025_5828_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50a/12036194/fa51d29cd11f/13018_2025_5828_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c50a/12036194/fa51d29cd11f/13018_2025_5828_Fig1_HTML.jpg

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Very high prevalence of osteosarcopenia in hip fracture patients: risk and protective factors.

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本文引用的文献

[1]
Vibration therapy as an intervention for trochanteric hip fractures - A randomized double-blinded, placebo-controlled trial.

J Orthop Translat. 2025-1-25

[2]
From Clinical to Benchside: Lacticaseibacillus and Faecalibacterium Are Positively Associated With Muscle Health and Alleviate Age-Related Muscle Disorder.

Aging Cell. 2025-5

[3]
Short-chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice.

J Cachexia Sarcopenia Muscle. 2024-12

[4]
Associations between Osteosarcopenia and Falls, Fractures, and Frailty in Older Adults: Results From the Canadian Longitudinal Study on Aging (CLSA).

J Am Med Dir Assoc. 2024-1

[5]
Prevalence and risk factors of osteosarcopenia: a systematic review and meta-analysis.

BMC Geriatr. 2023-6-15

[6]
The role of obesity in sarcopenia and the optimal body composition to prevent against sarcopenia and obesity.

Front Endocrinol (Lausanne). 2023

[7]
Muscle plays a more superior role than fat in bone homeostasis: A cross-sectional study of old Asian people.

Front Endocrinol (Lausanne). 2022

[8]
Deciphering the "obesity paradox" in the elderly: A systematic review and meta-analysis of sarcopenic obesity.

Obes Rev. 2023-2

[9]
Proximal Femoral Fractures in the Elderly: A Few Things to Know, and Some to Forget.

Medicina (Kaunas). 2022-9-20

[10]
Cephalomedullary nailing for reverse oblique intertrochanteric fractures 31A3 (AO/OTA).

Orthop Rev (Pavia). 2022-10-13

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