Montero Rebeca I, Dionicio Cinthia L, Noris Gino, Piña-Pozas Maricela, Santana Carla, Gómez Rocío
Biología Molecular Diagnóstica, Querétaro, Qro, Mexico.
Secretaría de Salud, Iguala, Gro, Mexico.
Front Genet. 2025 Apr 14;16:1558189. doi: 10.3389/fgene.2025.1558189. eCollection 2025.
Since host genetics is one of the primary factors contributing to COVID-19 susceptibility and its clinical progression, several studies have focused on analysing the implications of genetic polymorphisms associated with COVID-19. These studies particularly emphasise on common variants in genes that are involved in the viral mechanism of host entry and in the host's response to infection. In this study, we explored the participation of 24 single nucleotide polymorphisms located on the , , , , and genes in SARS-CoV-2 infection susceptibility. Three of these SNPs in (rs75603675, OR = 1.86, CI = 1.29-2.66, ≤ 0.001; rs4303795, OR = 1.98, CI = 1.38-2.84, ≤ 0.001 and rs8134378, OR = 2.59, CI = 1.28-5.21, ≤ 0.01) had a significant association with an increased risk of infection. When comparing haplotype frequency distributions, the haplotypes CAG (OR = 7.34, CI = 5.51-9.77), AGA (OR = 2.46, CI = 1.12-5.44), and AGG (OR = 1.59, CI = 1.17-2.16) presented significant associations, suggesting that influences SARS-CoV-2 infection susceptibility within Mexican Mestizos. These risk alleles and their haplotypes were found more frequently in the case group than in the reference group, contributing to at least a twofold increase in the risk of SARS-CoV-2 infection, a finding that was reinforced by meta-analyses.
由于宿主遗传学是导致新冠病毒易感性及其临床进展的主要因素之一，多项研究聚焦于分析与新冠病毒相关的基因多态性的影响。这些研究特别强调参与病毒进入宿主机制以及宿主对感染反应的基因中的常见变异。在本研究中，我们探究了位于 、 、 、 、 及 基因上的24个单核苷酸多态性在新冠病毒感染易感性中的作用。其中位于 基因上的3个单核苷酸多态性（rs75603675，优势比=1.86，可信区间=1.29 - 2.66，P≤0.001；rs4303795，优势比=1.98，可信区间=1.38 - 2.84，P≤0.001；rs8134378，优势比=2.59，可信区间=1.28 - 5.21，P≤0.01）与感染风险增加显著相关。比较单倍型频率分布时，单倍型CAG（优势比=7.34，可信区间=5.51 - 9.77）、AGA（优势比=2.46，可信区间=1.12 - 5.44）和AGG（优势比=1.59，可信区间=1.17 - 2.16）呈现出显著关联，表明 在墨西哥混血人群中影响新冠病毒感染易感性。这些风险等位基因及其单倍型在病例组中比在参照组中更频繁地被发现，导致新冠病毒感染风险至少增加两倍，这一发现通过荟萃分析得到了加强。
