妊娠期常染色体显性多囊肾病概述

Overview of ADPKD in Pregnancy.

作者信息

Campbell Ruth E, Edelstein Charles L, Chonchol Michel

机构信息

Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

出版信息

Kidney Int Rep. 2025 Jan 2;10(4):1011-1019. doi: 10.1016/j.ekir.2024.12.035. eCollection 2025 Apr.

DOI:10.1016/j.ekir.2024.12.035

PMID:40303224

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12034866/

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is a systemic disorder that often affects patients in their third to fifth decades of life and is characterized by kidney cysts, chronic kidney disease (CKD), hypertension, and hepatic cysts. The development of clinical symptoms often coincides with childbearing years. Consequently, there are several considerations regarding pregnant patients with ADPKD. In this review, we detail the effects and management of ADPKD in the peripartum period and discuss family planning options, including assisted reproductive techniques (ART) and preimplantation genetic testing.

摘要

常染色体显性多囊肾病（ADPKD）是一种全身性疾病，通常在患者30至50岁时发病，其特征为肾囊肿、慢性肾脏病（CKD）、高血压和肝囊肿。临床症状的出现往往与育龄期重合。因此，对于患有ADPKD的孕妇有几个需要考虑的方面。在本综述中，我们详细阐述了ADPKD在围产期的影响及管理，并讨论了计划生育选择，包括辅助生殖技术（ART）和植入前基因检测。