Wang Weilin, Wang Zhenhui, Wang Linghua, Li Suping, Liu Jiangling, Huang Yaqin, Liu Jun, Zhu Chun, Zhang Juan, Li Cairong, Yang Chunjia, Chen Qiong, Wang Wenqin, Deng Shulin, Du Yiming
Department of Neonatology, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, China.
Department of Obstetrics, Hunan Provincial Maternal and Child Health Care Hospital, University of South China, Changsha, Hunan, China.
Front Pediatr. 2025 Apr 15;13:1521908. doi: 10.3389/fped.2025.1521908. eCollection 2025.
Early-onset sepsis (EOS) remains an important issue in neonatal units. Characteristics of EOS from China have not been fully revealed yet. Our aim is to investigate epidemiology, microbiology and clinical feature of EOS in a Chinese maternal and child healthcare centre.
This is a retrospective observational study of EOS infants born in or admitted to Hunan Provincial Maternal and Child Health Care Hospital from January 1, 2017 to December 31, 2023.
During the study period, there were 131 neonatal infections. The incidence of EOS was 1.12 (95% CI 0.94-1.33) per 1,000 live births or 3.85 (95% CI 3.22-4.56) per 1,000 admissions. Coagulase-negative staphylococci (CoNS) ( = 43, 32.3%), group B (GBS) ( = 24, 18.0%) and ( = 18, 13.5%) were the predominant pathogens. GBS screening test was performed before delivery in 77.7% mothers of all infants with EOS, and 12.9% of screening results were positive. Among the main pathogens causing EOS, 86% of CoNS strains were resistant to penicillin, while all GBS strains were susceptible to penicillin.
We report a high burden of EOS among infants in the maternal and child healthcare centre from China. CoNS was the most frequent pathogen causing EOS. Longitudinal epidemiologic surveillance is required to improve empiric antibiotic treatment of EOS.
早发型败血症（EOS）仍是新生儿病房的一个重要问题。中国EOS的特征尚未完全揭示。我们的目的是调查一家中国妇幼保健中心EOS的流行病学、微生物学和临床特征。
这是一项对2017年1月1日至2023年12月31日在湖南省妇幼保健院出生或入院的EOS婴儿的回顾性观察研究。
在研究期间，有131例新生儿感染。EOS的发病率为每1000例活产1.12（95%CI 0.94-1.33）或每1000例入院3.85（95%CI 3.22-4.56）。凝固酶阴性葡萄球菌（CoNS）（n = 43，32.3%）、B族链球菌（GBS）（n = 24，18.0%）和大肠埃希菌（n = 18，13.5%）是主要病原体。所有EOS婴儿的母亲中，77.7%在分娩前进行了GBS筛查试验，筛查结果阳性率为12.9%。在引起EOS的主要病原体中，86%的CoNS菌株对青霉素耐药，而所有GBS菌株对青霉素敏感。
我们报告了中国妇幼保健中心婴儿中EOS的高负担。CoNS是引起EOS最常见的病原体。需要进行纵向流行病学监测以改善EOS的经验性抗生素治疗。
