Zhang Xiaoyi, Li Shenghao, Hao Liyuan, Jia Fukang, Yu Fei, Hu Xiaoyu
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Infectious Diseases, Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, No.39, Shierqiao Road, Jinniu District, Chengdu, Sichuan, China.
J Transl Med. 2025 Apr 30;23(1):493. doi: 10.1186/s12967-025-06278-9.
As a research hotspot in the field of regenerative medicine, hepatocyte regeneration has great potential in the treatment of liver diseases. This paper comprehensively summarizes the diverse sources of hepatocyte regeneration and its complex influencing factors, and deeply discusses the typical mechanism. According to the existing research, we observed that Wnt signaling pathway and Notch signaling pathway can play a synergistic role in the process of hepatocyte regeneration. So we further analyzed the crosstalk between Wnt and Notch signal pathway and the cross mechanism with TGF-β, YAP/TAZ pathway during regeneration. Despite the remarkable progress in the study of liver regeneration at the cellular and molecular levels, the comprehensive understanding of the fine regulation of influencing factors and the interaction between mechanisms still needs to be deepened. This paper aims to systematically analyze the interaction between influencing factors and classical mechanisms of hepatocyte regeneration by integrating multi-group data and advanced bioinformatics methods, so as to provide feasible ideas for the treatment of liver diseases and lay a solid theoretical foundation for the future development of regenerative medicine. It is believed that focusing on the rational development of innovative means such as inducing gene tendentiousness expression and anti-aging therapy, and in-depth analysis of the complex interactive network between hepatocyte regeneration mechanisms are expected to open up a new road for the development of more effective treatment strategies for liver diseases.
作为再生医学领域的研究热点，肝细胞再生在肝脏疾病治疗中具有巨大潜力。本文全面总结了肝细胞再生的多种来源及其复杂的影响因素，并深入探讨了其典型机制。根据现有研究，我们观察到Wnt信号通路和Notch信号通路在肝细胞再生过程中可发挥协同作用。因此，我们进一步分析了Wnt与Notch信号通路之间的相互作用以及再生过程中与TGF-β、YAP/TAZ通路的交叉机制。尽管在细胞和分子水平上肝脏再生研究取得了显著进展，但对影响因素的精细调控以及机制之间相互作用的全面理解仍有待深化。本文旨在通过整合多组数据和先进的生物信息学方法，系统分析肝细胞再生影响因素与经典机制之间的相互作用，从而为肝脏疾病治疗提供可行思路，并为再生医学的未来发展奠定坚实的理论基础。相信关注诱导基因倾向性表达和抗衰老治疗等创新手段的合理开发，深入分析肝细胞再生机制之间复杂的交互网络，有望为开发更有效的肝脏疾病治疗策略开辟一条新路。
