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中国医院重症监护病房中心静脉导管相关血流感染率：一项荟萃分析。

Central line-associated bloodstream infection rates in intensive care units of China's hospitals: a meta-analysis.

作者信息

Cai Minghong, Jiang Xiaoyan, Chen Jing, Wu Jiayu, Lyu Yu, Xiang Qian

机构信息

Healthcare-Associated Infection Control Center, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

出版信息

Front Public Health. 2025 Apr 16;13:1480428. doi: 10.3389/fpubh.2025.1480428. eCollection 2025.

DOI:10.3389/fpubh.2025.1480428
PMID:40308929
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12040942/
Abstract

BACKGROUND AND AIM

Various reasons have hindered accurate reporting of the central line-associated bloodstream infection (CLABSI) rates in China's hospital ICUs. This study conducts a meta-analysis to provide a precise assessment of CLABSI rates in these units.

METHODS

Adhering to the PRISMA guidelines, a systematic search was conducted in PubMed, Web of Science, Embase, CNKI, Wanfang and Weipu from January 2008 to December 2023. Selection of literature followed strict criteria, ensuring relevant data extraction. A random-effects model facilitated the meta-analysis.

RESULTS

The analysis incorporated 23 studies (PubMed: 5, Web of Science: 4, Embase: 1, CNKI: 9, Wanfang: 2, Weipu: 2). It revealed an overall weighted CLABSI rate in China's ICUs of 2.65‰ (95% CI: 2.57-2.73‰), with 3.12‰ in adult ICU (95% CI: 2.70-3.54‰) and 2.57‰ in pediatric ICUs (95% CI: 2.49-2.66‰). Notably, adult ICUs in North of China recorded the highest rate at 5.13‰ (95% CI: 4.23-6.02‰), and pediatric ICUs in East of China had 3.35‰ (95% CI: 2.85-3.85‰).

CONCLUSION

The study indicates that CLABSI rates in China's ICUs surpass those reported in national healthcare reports and the US CDC-NHSN data. This underscores the urgency for enhanced surveillance and infection control. The findings stress the need for standardized surveillance definitions and methods to truly represent CLABSI epidemiology and develop effective prevention strategies.

摘要

背景与目的

多种因素阻碍了中国医院重症监护病房（ICU）中心静脉导管相关血流感染（CLABSI）发生率的准确报告。本研究进行荟萃分析，以精确评估这些科室的CLABSI发生率。

方法

遵循PRISMA指南，于2008年1月至2023年12月在PubMed、科学网、Embase、中国知网、万方和维普进行系统检索。文献选择遵循严格标准，确保相关数据提取。采用随机效应模型进行荟萃分析。

结果

分析纳入23项研究（PubMed：5项、科学网：4项、Embase：1项、中国知网：9项、万方：2项、维普：2项）。结果显示，中国ICU的总体加权CLABSI发生率为2.65‰（95%CI：2.57 - 2.73‰），成人ICU为3.12‰（95%CI：2.70 - 3.54‰），儿科ICU为2.57‰（95%CI：2.49 - 2.66‰）。值得注意的是，中国北方的成人ICU发生率最高，为5.13‰（95%CI：4.23 - 6.02‰），中国东部的儿科ICU为3.35‰（95%CI：2.85 - 3.85‰）。

结论

该研究表明，中国ICU的CLABSI发生率高于国家医疗报告和美国疾病控制与预防中心国家医疗安全网络（US CDC - NHSN）数据中的报告率。这凸显了加强监测和感染控制的紧迫性。研究结果强调需要标准化的监测定义和方法，以真实反映CLABSI流行病学情况并制定有效的预防策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/6403a3452318/fpubh-13-1480428-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/f5af87552696/fpubh-13-1480428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/c7909405fc74/fpubh-13-1480428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/92185c18af3a/fpubh-13-1480428-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/a3510d05bc44/fpubh-13-1480428-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/6403a3452318/fpubh-13-1480428-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/f5af87552696/fpubh-13-1480428-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/c7909405fc74/fpubh-13-1480428-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/92185c18af3a/fpubh-13-1480428-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/a3510d05bc44/fpubh-13-1480428-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/331a/12040942/6403a3452318/fpubh-13-1480428-g005.jpg

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