肠道微生物群与心理健康的关联以及益生菌对精神疾病的影响：一项荟萃分析和系统评价。
Association of Gut-Microbiome and mental health and effects of probiotics on psychiatric disorders: A Meta-analysis and systematic review.
作者信息
Goel Ramita, Gupta Bhupesh, Satodiya Vimal Naranbhai, Vala Ashok Ukabhai, Dabhi Hetal, Mittal Anshu
机构信息
MMIMSR (Maharishi Markandeshwar Institute of Medical Science and Research), Mullana, Haryana, India.
Inland Psychiatric Medical Group, Lancaster, California, United States of America.
出版信息
Niger Med J. 2025 Apr 3;66(1):13-25. doi: 10.71480/nmj.v66i1.601. eCollection 2025 Jan-Feb.
BACKGROUND
A correlation between gut microbiome and mental health has drawn significant attention lately. The effects of microbiome microorganisms and their byproducts on disease states represent a complex and dynamic field of study. The objective of this article is to review the association of gut microbes and mental health and the effects of probiotics on psychiatric disorders, if any.
METHODOLOGY
This meta-analysis was conducted using the PRISMA standards. We have compiled the most recent advancements in the field according to human research published in this Systematic review and meta-analysis.
RESULTS
The forest plot analysis revealed that probiotics or probiotics combined with other intervention modalities did significantly reduce some extent of mental disorders in comparison to the control group (Standardized mean difference) SMD = 0.95, 95% Confidence Interval (CI): -6.52 to 8.42, P value< 0.01.
CONCLUSION
Overall, the reviewed literature supports the importance of gut microbiota-brain interaction in human mental illnesses, including the impact of probiotics on mental health outcomes and brain connection.
背景
肠道微生物群与心理健康之间的关联最近引起了广泛关注。微生物群及其副产物对疾病状态的影响代表了一个复杂且动态的研究领域。本文的目的是综述肠道微生物与心理健康的关联以及益生菌对精神疾病的影响（如有）。
方法
本荟萃分析采用PRISMA标准进行。我们根据该系统评价和荟萃分析中发表的人体研究，汇总了该领域的最新进展。
结果
森林图分析显示，与对照组相比，益生菌或益生菌与其他干预方式联合使用确实在一定程度上显著减轻了精神障碍（标准化均数差）SMD = 0.95，95%置信区间（CI）：-6.52至8.42，P值<0.01。
结论
总体而言，综述文献支持肠道微生物群与大脑相互作用在人类精神疾病中的重要性，包括益生菌对心理健康结果和大脑连接的影响。
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