Ma Changjun, Liu Ailian, Liu Jiahui, Wang Xiulin, Cong Fengyu, Li Ying, Liu Jing
School of Biomedical Engineering, Faculty of Medicine, Dalian University of Technology, Dalian, China.
Stem Cell Clinical Research Center, National Joint Engineering Laboratory, Regenerative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Front Neurosci. 2025 Apr 16;19:1526897. doi: 10.3389/fnins.2025.1526897. eCollection 2025.
Vascular cognitive impairment (VCI) encompasses a diverse range of syndromes, including mild cognitive impairment and vascular dementia (VaD), primarily attributed to cerebrovascular lesions and vascular risk factors. Its prevalence ranks second only to Alzheimer's disease (AD) in neuro diseases. The advancement of medical imaging technology, particularly magnetic resonance imaging (MRI), has enabled the early detection of structural, functional, metabolic, and cerebral connectivity alterations in individuals with VCI. This paper examines the utility of multimodal MRI in evaluating structural changes in the cerebral cortex, integrity of white matter fiber tracts, alterations in the blood-brain barrier (BBB) and glymphatic system (GS) activity, alteration of neurovascular coupling function, assessment of brain connectivity, and assessment of metabolic changes in patients with VCI.
血管性认知障碍（VCI）涵盖了多种综合征，包括轻度认知障碍和血管性痴呆（VaD），主要归因于脑血管病变和血管危险因素。其患病率在神经疾病中仅次于阿尔茨海默病（AD）。医学成像技术的进步，尤其是磁共振成像（MRI），使得能够早期检测VCI患者的结构、功能、代谢和脑连接性改变。本文探讨了多模态MRI在评估VCI患者大脑皮质结构变化、白质纤维束完整性、血脑屏障（BBB）和类淋巴系统（GS）活性改变、神经血管耦合功能改变、脑连接性评估以及代谢变化评估方面的效用。
