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Editing proteins inside a cell.
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Switchable inteins for conditional protein splicing.
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Protein Chemical Modification Inside Living Cells Using Split Inteins.
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Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins.
Science. 2025 May;388(6746):eadr5499. doi: 10.1126/science.adr5499. Epub 2025 May 1.
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Protein trans-splicing of multiple atypical split inteins engineered from natural inteins.
PLoS One. 2013 Apr 8;8(4):e59516. doi: 10.1371/journal.pone.0059516. Print 2013.
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In-cell fluorescence activation and labeling of proteins mediated by FRET-quenched split inteins.
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Construction of a small-molecule-integrated semisynthetic split intein for in vivo protein ligation.
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Post-translational control of protein function with light using a LOV-intein fusion protein.
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Conditional Split Inteins: Adaptable Tools for Programming Protein Functions.
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本文引用的文献

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Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins.
Science. 2025 May;388(6746):eadr5499. doi: 10.1126/science.adr5499. Epub 2025 May 1.
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Protein Splicing of Inteins: A Powerful Tool in Synthetic Biology.
Front Bioeng Biotechnol. 2022 Feb 21;10:810180. doi: 10.3389/fbioe.2022.810180. eCollection 2022.
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RNA editing with CRISPR-Cas13.
Science. 2017 Nov 24;358(6366):1019-1027. doi: 10.1126/science.aaq0180. Epub 2017 Oct 25.
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A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Science. 2012 Aug 17;337(6096):816-21. doi: 10.1126/science.1225829. Epub 2012 Jun 28.
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Development of a tandem protein trans-splicing system based on native and engineered split inteins.
J Am Chem Soc. 2005 May 4;127(17):6198-206. doi: 10.1021/ja042287w.
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Expanding the genetic code of Escherichia coli.
Science. 2001 Apr 20;292(5516):498-500. doi: 10.1126/science.1060077.
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Protein trans-splicing by a split intein encoded in a split DnaE gene of Synechocystis sp. PCC6803.
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Expressed protein ligation: a general method for protein engineering.
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Synthesis of proteins by native chemical ligation.
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