Liu Xiao, Zhang Quan-Guo
State Key Laboratory of Earth Surface Processes and Resource Ecology and MOE Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University Beijing China.
mLife. 2025 Mar 12;4(2):223-225. doi: 10.1002/mlf2.12158. eCollection 2025 Apr.
Evolutionary training of phages can help to counter bacterial resistance evolution. Here, we address whether metapopulation processes can enhance the evolution of phage infectivity. Our experiment with a model bacterium-phage system supported a prediction of long-term fluctuating selection dynamics. Specifically, metapopulations of several small habitats showed greater total infectivity ranges by supporting more diverse phages, compared with single large populations. Crucially, the advantage of several small habitats was conditioned on blocking bacterial dispersal within metapopulations. We conclude that well-designed metapopulation training programs can be useful for quick and easy preparation of cocktail phage materials.
噬菌体的进化训练有助于对抗细菌耐药性的演变。在此，我们探讨集合种群过程是否能够增强噬菌体感染性的进化。我们利用一个模型细菌 - 噬菌体系统进行的实验支持了长期波动选择动态的预测。具体而言，与单个大种群相比，由几个小栖息地组成的集合种群通过支持更多样化的噬菌体，显示出更大的总感染范围。至关重要的是，几个小栖息地的优势取决于阻止细菌在集合种群内扩散。我们得出结论，精心设计的集合种群训练计划对于快速简便地制备鸡尾酒噬菌体材料可能是有用的。
