Dong Jigang, Qi Ying, Sha Sha, Fu Chengrui, Xu Xiao, Li Baosheng
Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300000, China.
Qingdao People's Hospital Group (Jiaozhou), Jiaozhou Central Hospital of Qingdao, Qingdao, China.
BMC Cancer. 2025 May 2;25(1):824. doi: 10.1186/s12885-025-14119-7.
The effect of frequent whole-body CT scans during immune checkpoint inhibitor (ICI) therapy on patients' anti-tumor immunity.
We conducted a retrospective clinical study aimed to investigate the correlation between the frequency of CT scans during immune checkpoint inhibitor (ICI) therapy and the duration of remission (DOR) of ICI therapy in patients with stage IV non-small cell lung cancer (NSCLC). We constructed a hormonal mouse model and administered immune checkpoint inhibitor (ICI) therapy to mice, and radiated five whole-body CT scans to mice during ICI therapy to observe whether frequent whole-body CT scans had an effect on the antitumor effect of immunotherapy in mice.
The more frequent CT scans during patients' immune checkpoint inhibitor (ICI) treatment the longer the duration of remission (DOR) of ICI treatment. In a mouse model we observed that the addition of whole-body CT scanning radiation had a tendency to inhibit tumor growth in mice compared with the anti-PD-1 group alone.Frequent CT scanning radiation during the application of immune checkpoint inhibitor PD-1 increased the proportion of infiltrating CD8 + T cells in tumor tissues and significantly increased the proportion of IFNγ-secreting CD8 + T cells, and single-cell sequencing of the results also revealed that IFNγ and killing-related genes were significantly upregulated in tumor-infiltrating CD8T cells.
To our knowledge this is the first study on the effect of CT scan radiation on ICI.Our findings suggest that multiple CT scans during immune checkpoint inhibitor (ICI) treatment did not promote tumor progression, but instead a trend toward delayed tumor progression was observed.
探讨免疫检查点抑制剂（ICI）治疗期间频繁进行全身CT扫描对患者抗肿瘤免疫的影响。
我们进行了一项回顾性临床研究，旨在调查IV期非小细胞肺癌（NSCLC）患者在免疫检查点抑制剂（ICI）治疗期间CT扫描频率与ICI治疗缓解持续时间（DOR）之间的相关性。我们构建了激素小鼠模型，并对小鼠进行免疫检查点抑制剂（ICI）治疗，在ICI治疗期间对小鼠进行五次全身CT扫描，以观察频繁的全身CT扫描是否对小鼠免疫治疗的抗肿瘤效果有影响。
患者在免疫检查点抑制剂（ICI）治疗期间进行CT扫描的频率越高，ICI治疗的缓解持续时间（DOR）越长。在小鼠模型中，我们观察到与单独的抗PD-1组相比，添加全身CT扫描辐射有抑制小鼠肿瘤生长的趋势。在应用免疫检查点抑制剂PD-1期间频繁进行CT扫描辐射，可增加肿瘤组织中浸润性CD8 + T细胞的比例，并显著增加分泌IFNγ的CD8 + T细胞的比例，单细胞测序结果还显示肿瘤浸润性CD8T细胞中IFNγ和杀伤相关基因显著上调。
据我们所知，这是第一项关于CT扫描辐射对ICI影响的研究。我们的研究结果表明，在免疫检查点抑制剂（ICI）治疗期间进行多次CT扫描不会促进肿瘤进展，反而观察到有延迟肿瘤进展的趋势。
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