Bellamkonda Nikhil, Monroe Marcus M
Department of Otolaryngology-Head and Neck Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Ann Otol Rhinol Laryngol. 2025 Jul;134(7):527-532. doi: 10.1177/00034894251335402. Epub 2025 May 3.
To describe outcomes of patients with a history of cutaneous squamous cell carcinoma (cSCC) of the head and neck previously treated with definitive surgery and radiation therapy (RT), who undergo salvage surgery for disease recurrence. There is minimal data available on this cohort of patients.
This was a retrospective case series. Patients evaluated for advanced cSCC of the head and neck between 2003 and 2022 were reviewed. Those with a history of surgery and adjuvant RT undergoing salvage surgery for recurrence were included in the main cohort. Comparisons were made to patients undergoing primary/initial treatment, and to those undergoing salvage surgery for recurrence but without a history of adjuvant RT.
Of the 579 patients reviewed, 49 met inclusion criteria for the main cohort. Average length of follow up was 22 months. A total of 19 patients (38.8%) experienced recurrence, all within 14 months of salvage surgery. Among patents staged BWH T2b or T3, there was a 50% recurrence rate. Average overall survival following surgery was 35.6 months (95% CI = 24.7-46.4).
Patients in this cohort have a high rate of recurrence and an overall survival of approximately 3 years.
描述既往接受过根治性手术和放射治疗（RT）的头颈部皮肤鳞状细胞癌（cSCC）患者在疾病复发后接受挽救性手术的结局。关于这一患者群体的数据极少。
这是一项回顾性病例系列研究。对2003年至2022年间接受头颈部晚期cSCC评估的患者进行了回顾。主要队列纳入了有手术史且接受辅助放疗后因复发接受挽救性手术的患者。与接受初次/初始治疗的患者以及因复发接受挽救性手术但无辅助放疗史的患者进行了比较。
在579例接受评估的患者中，49例符合主要队列的纳入标准。平均随访时间为22个月。共有19例患者（38.8%）出现复发，均在挽救性手术后14个月内。在BWH分期为T2b或T3的患者中，复发率为50%。手术后的平均总生存期为35.6个月（95%CI = 24.7 - 46.4）。
该队列患者复发率高，总生存期约为3年。
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